Citation: SUN Jing, SONG Xing-Dong, CHEN Wen-Xiu, ZHAO Xuan-Hao, CHEN Jia-Xi, JIA Zhen-Bin, HAO Hong-Qing. Synthesis, Crystal Structure and Interactions with G-Quadruplex Structures of [Ru(dpq)₂L]⁴⁺[J]. Chinese Journal of Inorganic Chemistry, ;2015, (5): 865-872. doi: 10.11862/CJIC.2015.142 shu

Synthesis, Crystal Structure and Interactions with G-Quadruplex Structures of [Ru(dpq)₂L]⁴⁺

1.
1 School of Pharmacy, Guangdong Medical College, Dongguan, Guangdong 523808, China;
2.
2 School of Chemistry and Enviomment, Jiaying University, Meizhou, Guangdong 514015, China

Corresponding author: SUN Jing, HAO Hong-Qing,
Received Date: 28 November 2014
Available Online: 22 March 2015
Fund Project: 国家自然科学基金(No.21101034) (No.21101034)广东省优秀青年教师培养计划项目(No.Yq2013086,Yq2013151) (No.Yq2013086,Yq2013151)东莞市科技计划项目(No.2011108102046) (No.2011108102046)广东省大学生创新课题(No.1057112037)项目,2014年广东省本科高校教学质量与教学改革工程立项建设项目资助。 (No.1057112037)

Based on cis-[Ru(dpq)₂Cl₂]·2H₂O (dpq=dipyrido[3,2-d:2',3'-f]quinoxaline) and 5,5'-di(1-(triethylamm-onio)methyl)-2,2'-dipyridyl cation ligand (L), the complex [Ru(dpq)₂L](PF₆)₄ was synthesized and structurally characterized. The interactions of the complex with different G-quadruplexes were investigated. FRET melting assay proved that the complex bonds more strongly to h-telo than to promoters, such as c-myc and bcl2. CD studies show that Ru(Ⅱ) complex can induce the formation of parallel G-quadruplex of h-telo in the absence of Na⁺ or K⁺. Results of absorption and emission titration indicated that the complex has a higher DNA affinity with h-telo in K⁺ buffer than in Na⁺ buffer.
- Ru(Ⅱ) complex;G-quadruplex DNA;selectivity
1. [1]
  [1] Huppert J L, Balasubramanian S. Nucleic Acids Res., 2005, 33:2908-2916
2. [2]
  [2] Huppert J L. Chem. Soc. Rev., 2008,37:1375-1384
3. [3]
  [3] Murat P, Singh Y, Defrancq E. Chem. Soc. Rev., 2011,40: 5293-5307
4. [4]
  [4] Huppert J L, Balasubramanian S. Nucleic Acids Res., 2007, 35:406-413
5. [5]
  [5] Todd A K, Johnston M, Neidle S. Nucleic Acids Res., 2005, 33:2901-2907
6. [6]
  [6] Reed J E, White A J P, Neidleb S, et al. Dalton Trans., 2009: 2558-2568
7. [7]
  [7] Kim N W, Piatyszek M A, Prowse K R, et al. Science, 1994, 266:2011-2015
8. [8]
  [8] Shay J W, Bacchetti S. Eur. J. Cancer, 1997,33:787-791
9. [9]
  [9] Kelland L R. Anticancer Drugs, 2000,11:503-513
10. [10]
  [10] Suntharalingam K, Gupta D, Miguel P J S, et al. Chem. Eur. J., 2010,16:3613-3616
11. [11]
  [11] Finkel T, Serrano M, Blasco M A. Nature, 2007,448:767-774
12. [12]
  [12] Bertrand H, Monchaud D, Cian A D, et al. Org. Biomol. Chem., 2007,5:2555-2559
13. [13]
  [13] SUN Jing(孙静), CHEN Jia-Xi(陈嘉曦), LIN Hai-Ling(林海玲), et al. Chinese J. Inorg. Chem.(无机化学学报), 2012, 28:45-49
14. [14]
  [14] Jain A K, Paul A, Maji B, et al. J. Med. Chem., 2012,55: 2981-2993
15. [15]
  [15] Chen X, Wu J H, Lai Y W, et al. Dalton Trans., 2013:4386-4397
16. [16]
  [16] Shi S, Huang H L, Gao X, et al. J. Inorg. Biochem., 2013, 121:19-27
17. [17]
  [17] An Y, Lin Y Y, Wang H, et al. Dalton Trans., 2006:2066-2071
18. [18]
  [18] Paw W, Eisenberg R. Inorg. Chem., 1997,36:2287-2293
19. [19]
  [19] Collins J G, Sleeman A D, Aldrich-Wright J R, et al. Inorg. Chem., 1998,37:3133-3141
20. [20]
  [20] Deshpande M S, Kumbhar A A, Kumbhar A S, et al. Bioco-njugate Chem., 2009,20:447-459
21. [21]
  [21] Sheldrick G M. SADABS, University of Göttingen, Germany, 1996.
22. [22]
  [22] Sheldrick G M. SHELXS-97 and SHELXL-97, University of Göttingen, Germany, 1996.
23. [23]
  [23] Haq I, Lincoln P, Suh D, et al. J. Am. Chem. Soc., 1995, 117:4788-4796
24. [24]
  [24] Haq I, Trent J O, Chowdhry B Z, et al. J. Am. Chem. Soc., 1999,121:1768-1779
25. [25]
  [25] Santra B K, Menon M, Pal C K, et al. Dalton Trans., 1997: 1387-1393
26. [26]
  [26] Sun J, Wu S, An Y, et al. Polyhedron, 2008,27:2845-2850
27. [27]
  [27] Rillema D P, Jones D S, Woods C, et al. Inorg. Chem., 1992,31:2935-2938
28. [28]
  [28] Khatua S, Samanta D, Bats J W, et al. Inorg. Chem., 2012, 51:7075-7086
29. [29]
  [29] Mergny J L, Maurizot J C. ChemBioChem, 2001,2:124-132
30. [30]
  [30] Rezler E M, Seenisamy J, Bashyam S, et al. J. Am. Chem. Soc., 2005,127:9439-9447
31. [31]
  [31] Ambrus A, Chen D, Dai J X, et al. Nucleic Acids Res., 2006,34:2723-2735
32. [32]
  [32] Xu Y, Noguchi Y, Sugiyama H. Bioorg. Med. Chem., 2006, 14:5584-5591
33. [33]
  [33] Antonacci C, Chaires J B, Sheardy R D. Biochemistry, 2007,46:4654-4660
34. [34]
  [34] Dai J X, Punchihewa C, Ambrus A, et al. Nucleic Acids Res., 2007,35:2440-2450
35. [35]
  [35] Li W, Wu P, Ohmichi T, et al. FEBS Lett., 2002,526:77-81
36. [36]
  [36] Zheng X H, Zhong Y F, Tan C P, et al. Dalton Trans., 2012: 11807-11812
37. [37]
  [37] Chen L M, Liu J, Chen J C, et al. J. Inorg. Biochem., 2008, 102:330-341
38. [38]
  [38] Carter M T, Rodriguez M, Bard A J. J. Am. Chem. Soc., 1989,111:8901-8911
39. [39]
  [39] Maheswari P U, Palaniandavar M. J. Inorg. Biochem., 2004, 98:219-230
40. [40]
  [40] Shi S, Geng X T, Zhao J, et al. Biochimie, 2010,92:370-377
41. [41]
  [41] Rajput C, Rutkaite R, Swanson L, et al. Chem. Eur. J., 2006,12:4611-4619
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Synthesis, Crystal Structure and Interactions with G-Quadruplex Structures of [Ru(dpq)₂L]⁴⁺