Citation: SUN Jing, SONG Xing-Dong, CHEN Wen-Xiu, ZHAO Xuan-Hao, CHEN Jia-Xi, JIA Zhen-Bin, HAO Hong-Qing. Synthesis, Crystal Structure and Interactions with G-Quadruplex Structures of [Ru(dpq)₂L]⁴⁺[J]. Chinese Journal of Inorganic Chemistry, ;2015, (5): 865-872. doi: 10.11862/CJIC.2015.142 shu

Synthesis, Crystal Structure and Interactions with G-Quadruplex Structures of [Ru(dpq)₂L]⁴⁺

1.
1 School of Pharmacy, Guangdong Medical College, Dongguan, Guangdong 523808, China;
2.
2 School of Chemistry and Enviomment, Jiaying University, Meizhou, Guangdong 514015, China

Corresponding author: SUN Jing, HAO Hong-Qing,
Received Date: 28 November 2014
Available Online: 22 March 2015
Fund Project: 国家自然科学基金(No.21101034) (No.21101034)广东省优秀青年教师培养计划项目(No.Yq2013086,Yq2013151) (No.Yq2013086,Yq2013151)东莞市科技计划项目(No.2011108102046) (No.2011108102046)广东省大学生创新课题(No.1057112037)项目,2014年广东省本科高校教学质量与教学改革工程立项建设项目资助。 (No.1057112037)

Based on cis-[Ru(dpq)₂Cl₂]·2H₂O (dpq=dipyrido[3,2-d:2',3'-f]quinoxaline) and 5,5'-di(1-(triethylamm-onio)methyl)-2,2'-dipyridyl cation ligand (L), the complex [Ru(dpq)₂L](PF₆)₄ was synthesized and structurally characterized. The interactions of the complex with different G-quadruplexes were investigated. FRET melting assay proved that the complex bonds more strongly to h-telo than to promoters, such as c-myc and bcl2. CD studies show that Ru(Ⅱ) complex can induce the formation of parallel G-quadruplex of h-telo in the absence of Na⁺ or K⁺. Results of absorption and emission titration indicated that the complex has a higher DNA affinity with h-telo in K⁺ buffer than in Na⁺ buffer.
- Ru(Ⅱ) complex;G-quadruplex DNA;selectivity
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Synthesis, Crystal Structure and Interactions with G-Quadruplex Structures of [Ru(dpq)₂L]⁴⁺