Citation: JIANG Wu-Jiu, WU Xu-Meng, LIU Chao, YU Jiang-Xi, ZHU Xiao-Ming, FENG Yong-Lan, ZHANG Fu-Xing, KUANG Dai-Zhi. Syntheses, Crystal Structures and Biological Activity of Schiff Base Organotin Complexes Based on o-Vanillin and 2-Amino-4-nitrophenol[J]. Chinese Journal of Inorganic Chemistry, ;2015, 31(7): 1321-1328. doi: 10.11862/CJIC.2015.116 shu

Syntheses, Crystal Structures and Biological Activity of Schiff Base Organotin Complexes Based on o-Vanillin and 2-Amino-4-nitrophenol

1.
1 Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province; Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China;
2.
2 Department of Chemistry and Life Science, Xiangnan University, Chenzhou, Hunan 423043, China

Corresponding author: KUANG Dai-Zhi,
Received Date: 28 December 2014
Available Online: 26 January 2015
Fund Project: 湖南省科技计划项目(No.2013TZ2025, 2014NK3086, 2014FJ3060) (No.2013TZ2025, 2014NK3086, 2014FJ3060)自然科学基金(No.13JJ3112) (No.13JJ3112) 湖南省普通高校重点实验室开放基金项目(No.13K105, 14K014) (No.13K105, 14K014) 湖南省教育厅基金项目(No.14C0171) (No.14C0171) 功能金属有机材料湖南省普通高校重点实验室开放基金项目 (No.13K01, 13K04, GN14K01)资助。 (No.13K01, 13K04, GN14K01)

Schiff base organotin complexes 1 and 2 have been synthesized via the reaction of the o-Vanillin-2-amino-4-nitrophenol Schiff base(H₂L) with the dibutyltin oxide and the dibenzyltin dichloride, respectively. The complexes have been characterized by IR, ¹H NMR, ¹³C NMR spectra, elemental analysis and the crystal structures have been determined by X-ray diffraction. The anticancer activity of H₂L, 1 and 2 against five species of cancer cell which are Hela, MCF7, HepG2, Colo205, NCI-H460 were tested respectively, and the tests showed that complex 1 was more active than carboplatin against tested carcinoma cell lines and has a potential application of drug preparation. The interaction between Schiff base ligand, complex 2 and Herring sperm DNA were studied by EB fluorescent probe, the result shows that fluorescence quenching was really resulted from the synergistic effect of the Schiff base ligand. CCDC: 939077, 1; 939078, 2.
- organotin;Schiff base;crystal structure;biological activity
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