Citation: LI Zhi-Xi, HU Ming, LIU Chao, YANG Xiao-Liang. Structural Characterization and Artificial Nuclease Activity of Transition Metal Complexes of Cyclam Derivatives[J]. Chinese Journal of Inorganic Chemistry, ;2015, (1): 127-132. doi: 10.11862/CJIC.2015.023 shu

Structural Characterization and Artificial Nuclease Activity of Transition Metal Complexes of Cyclam Derivatives

1.
State Key Laboratory of Coordination Chemistry, Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China

Corresponding author: YANG Xiao-Liang,
Received Date: 11 August 2014
Available Online: 24 October 2014
Fund Project: 国家自然科学基金(No.21131003)资助项目. (No.21131003)

Acyclam-based ligand: tetratert-butyl ((4,11-dimethyl^-1,4,8,11-tetraazacyclotetradecane^-1,8-diyl)bis (propane-3,2,1-triyl)) tetracarbamatev (L1), and its metal complexes [Zn(L₁)Cl₂] (1), [Ni(L₁)Cl₂] (2) and [Cu(L₁)Cl₂] (3) were designed and synthesized. L1 has a C₂ symmetrical structure and the ¹H chemical shift of the same carbon was different because of the influence of cyclam ring. The metal binding site of the L₁ was confirmed by 2D [¹H, ¹⁵N] HSQC by comparing the chemical shift of N of the branched chains of the ligand that of with the corresponding metal complex. The co-existence of two configuration was characterized by ¹³C VT NMR combined with 2D [¹H, ¹⁵N] HSQC NMR and trans-Ⅲ was confirmed to be the main configuration for complex 1. The cleavage activity of the ligand L₁ and the complexes 1~3 was investigated in detail under physiological conditions. Agarose gel electrophoresis experiments showed that the complex 3 possesses interesting nuclease activity in the present of ascorbate; No matter the hydrolysis or oxidation, the ligand L₁ and complex 1, and 2 were negative to DNA at the experimental conditions.
- cyclam derivatives;mono-metal complex;configuration;artificial nuclease
References
1. [1]
  [1] Hunter T M, Simpson D P, Smith A M, et al. Chem. Eur. J., 2007,13:40-50
2. [2]
  [2] Liang F, Wan S, Xiong X, et al. Curr. Med. Chem., 2006,13: 711-727
3. [3]
  [3] Ross A, Choi J H, Hunter T M, et al. Dalton Trans., 2012, 41:6408-6418
4. [4]
  [4] Canaple L, Husken, J H, et al. Bioconjugate Chem., 2002, 13:94-951
5. [5]
  [5] Korupoju S R, Mangayarkarasi N, Zacharias P S, et al. Inorg. Chem., 2002,41:4099-4101
6. [6]
  [6] Xia C Q, Jiang N, Zhang J, et al. Bioorg. Med. Chem., 2006, 14:5756-5764
7. [7]
  [7] Zhang Q, Xiang Y, Liang D W, et al. Bioorg. Med. Chem. Lett., 2012,22:1814-1817
8. [8]
  [8] Li C, Zhao F F, Huang Y N, et al. Bioconjugate Chem., 2012, 23:1832-1837
9. [9]
  [9] Joyner J C, Reichfield J, Cowan J A. J. Am. Chem. Soc., 2011,133:15613-15626
10. [10]
  [10] Sheng X, Guo X, Lu X M, et al. Bioconjugate Chem., 2008, 19:490-498
11. [11]
  [11] Ramalingam K, Raju N, Nanjappan P, et al. Tetrahedron, 1995,51:2875-2894
12. [12]
  [12] Kobelev S M, Averin A D, Buryak A K, et al. Hetercycles, 2011,82:1447-1476
13. [13]
  [13] Yu M F, Price J R, Jensen P, et al. Inorg. Chem., 2011,50: 12823-12835
14. [14]
  [14] Stephen J P, Sadler P J. Chem. Commun., 2004:306-307
15. [15]
  [15] Miyoshi T, Hayashi S, Imashiro F, et al. Macromolecules, 2002,35:2624-2632
16. [16]
  [16] Liang X Y, Weishaupl M, Parkinson J A, et al. Chem. Eur. J., 2003,9:4709-4717
17. [17]
  [17] (a)Molphy Z, Prisecaru A, Slator C, et al. Inorg. Chem., 2014,53:5392-5404 (b)Zhou W, Wang X Y, Hu M, et al. Chem. Sci., 2014,5: 2761-2770
1. [1]
  [1] Hunter T M, Simpson D P, Smith A M, et al. Chem. Eur. J., 2007,13:40-50
2. [2]
  [2] Liang F, Wan S, Xiong X, et al. Curr. Med. Chem., 2006,13: 711-727
3. [3]
  [3] Ross A, Choi J H, Hunter T M, et al. Dalton Trans., 2012, 41:6408-6418
4. [4]
  [4] Canaple L, Husken, J H, et al. Bioconjugate Chem., 2002, 13:94-951
5. [5]
  [5] Korupoju S R, Mangayarkarasi N, Zacharias P S, et al. Inorg. Chem., 2002,41:4099-4101
6. [6]
  [6] Xia C Q, Jiang N, Zhang J, et al. Bioorg. Med. Chem., 2006, 14:5756-5764
7. [7]
  [7] Zhang Q, Xiang Y, Liang D W, et al. Bioorg. Med. Chem. Lett., 2012,22:1814-1817
8. [8]
  [8] Li C, Zhao F F, Huang Y N, et al. Bioconjugate Chem., 2012, 23:1832-1837
9. [9]
  [9] Joyner J C, Reichfield J, Cowan J A. J. Am. Chem. Soc., 2011,133:15613-15626
10. [10]
  [10] Sheng X, Guo X, Lu X M, et al. Bioconjugate Chem., 2008, 19:490-498
11. [11]
  [11] Ramalingam K, Raju N, Nanjappan P, et al. Tetrahedron, 1995,51:2875-2894
12. [12]
  [12] Kobelev S M, Averin A D, Buryak A K, et al. Hetercycles, 2011,82:1447-1476
13. [13]
  [13] Yu M F, Price J R, Jensen P, et al. Inorg. Chem., 2011,50: 12823-12835
14. [14]
  [14] Stephen J P, Sadler P J. Chem. Commun., 2004:306-307
15. [15]
  [15] Miyoshi T, Hayashi S, Imashiro F, et al. Macromolecules, 2002,35:2624-2632
16. [16]
  [16] Liang X Y, Weishaupl M, Parkinson J A, et al. Chem. Eur. J., 2003,9:4709-4717
17. [17]
  [17] (a)Molphy Z, Prisecaru A, Slator C, et al. Inorg. Chem., 2014,53:5392-5404 (b)Zhou W, Wang X Y, Hu M, et al. Chem. Sci., 2014,5: 2761-2770
1. [1]
  Jianfeng Yan , Yating Xiao , Xin Zuo , Caixia Lin , Yaofeng Yuan . Comprehensive Chemistry Experimental Design of Ferrocenylphenyl Derivatives. University Chemistry, 2024, 39(4): 329-337. doi: 10.3866/PKU.DXHX202310005
2. [2]
  Xiaowei TANG , Shiquan XIAO , Jingwen SUN , Yu ZHU , Xiaoting CHEN , Haiyan ZHANG . A zinc complex for the detection of anthrax biomarker. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1850-1860. doi: 10.11862/CJIC.20240173
3. [3]
  Haitang WANG , Yanni LING , Xiaqing MA , Yuxin CHEN , Rui ZHANG , Keyi WANG , Ying ZHANG , Wenmin WANG . Construction, crystal structures, and biological activities of two Ln^Ⅲ₃ complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1474-1482. doi: 10.11862/CJIC.20240188
4. [4]
  Yonghui ZHOU , Rujun HUANG , Dongchao YAO , Aiwei ZHANG , Yuhang SUN , Zhujun CHEN , Baisong ZHU , Youxuan ZHENG . Synthesis and photoelectric properties of fluorescence materials with electron donor-acceptor structures based on quinoxaline and pyridinopyrazine, carbazole, and diphenylamine derivatives. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 701-712. doi: 10.11862/CJIC.20230373
5. [5]
  Yikai Wang , Xiaolin Jiang , Haoming Song , Nan Wei , Yifan Wang , Xinjun Xu , Cuihong Li , Hao Lu , Yahui Liu , Zhishan Bo . 氰基修饰的苝二酰亚胺衍生物作为膜厚不敏感型阴极界面材料用于高效有机太阳能电池. Acta Physico-Chimica Sinica, 2025, 41(3): 2406007-. doi: 10.3866/PKU.WHXB202406007
6. [6]
  Tianyun Chen , Ruilin Xiao , Xinsheng Gu , Yunyi Shao , Qiujun Lu . Synthesis, Crystal Structure, and Mechanoluminescence Properties of Lanthanide-Based Organometallic Complexes. University Chemistry, 2024, 39(5): 363-370. doi: 10.3866/PKU.DXHX202312017
7. [7]
  Wenjing ZHANG , Xiaoqing WANG , Zhipeng LIU . Recent developments of inorganic metal complex-based photothermal materials and their applications in photothermal therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2356-2372. doi: 10.11862/CJIC.20240254
8. [8]
  Hong Wu , Yuxi Wang , Hongyan Feng , Xiaokui Wang , Bangkun Jin , Xuan Lei , Qianghua Wu , Hongchun Li . Application of Computational Chemistry in the Determination of Magnetic Susceptibility of Metal Complexes. University Chemistry, 2025, 40(3): 116-123. doi: 10.12461/PKU.DXHX202405141
9. [9]
  Xin MA , Ya SUN , Na SUN , Qian KANG , Jiajia ZHANG , Ruitao ZHU , Xiaoli GAO . A Tb₂ complex based on polydentate Schiff base: Crystal structure, fluorescence properties, and biological activity. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1347-1356. doi: 10.11862/CJIC.20230357
10. [10]
  Jing WU , Puzhen HUI , Huilin ZHENG , Pingchuan YUAN , Chunfei WANG , Hui WANG , Xiaoxia GU . Synthesis, crystal structures, and antitumor activities of transition metal complexes incorporating a naphthol-aldehyde Schiff base ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2422-2428. doi: 10.11862/CJIC.20240278
11. [11]
  Jiaxun Wu , Mingde Li , Li Dang . The R eaction of Metal Selenium Complexes with Olefins as a Tutorial Case Study for Analyzing Molecular Orbital Interaction Modes. University Chemistry, 2025, 40(3): 108-115. doi: 10.12461/PKU.DXHX202405098
12. [12]
  Zuozhong Liang , Lingling Wei , Yiwen Cao , Yunhan Wei , Haimei Shi , Haoquan Zheng , Shengli Gao . Exploring the Development of Undergraduate Scientific Research Ability in Basic Course Instruction: A Case Study of Alkali and Alkaline Earth Metal Complexes in Inorganic Chemistry. University Chemistry, 2024, 39(7): 247-263. doi: 10.3866/PKU.DXHX202310103
13. [13]
  Lina Guo , Ruizhe Li , Chuang Sun , Xiaoli Luo , Yiqiu Shi , Hong Yuan , Shuxin Ouyang , Tierui Zhang . 层状双金属氢氧化物的层间阴离子对衍生的Ni-Al₂O₃催化剂光热催化CO₂甲烷化反应的影响. Acta Physico-Chimica Sinica, 2025, 41(1): 2309002-. doi: 10.3866/PKU.WHXB202309002
14. [14]
  Qilu DU , Li ZHAO , Peng NIE , Bo XU . Synthesis and characterization of osmium-germyl complexes stabilized by triphenyl ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1088-1094. doi: 10.11862/CJIC.20240006
15. [15]
  Wei Li , Ze Chang , Meihui Yu , Ying Zhang . Curriculum Ideological and Political Design of Piezoelectricity Measurement Experiments of Coordination Compounds. University Chemistry, 2024, 39(2): 77-82. doi: 10.3866/PKU.DXHX202308004
16. [16]
  Ji Qi , Jianan Zhu , Yanxu Zhang , Jiahao Yang , Chunting Zhang . Visible Color Change of Copper (II) Complexes in Reversible SCSC Transformation: The Effect of Structure on Color. University Chemistry, 2024, 39(3): 43-57. doi: 10.3866/PKU.DXHX202307050
17. [17]
  Cunling Ye , Xitong Zhao , Hongfang Wang , Zhike Wang . A Formula for the Calculation of Complex Concentrations Arising from Side Reactions and Its Applications. University Chemistry, 2024, 39(4): 382-386. doi: 10.3866/PKU.DXHX202310043
18. [18]
  Keweiyang Zhang , Zihan Fan , Liyuan Xiao , Haitao Long , Jing Jing . Unveiling Crystal Field Theory: Preparation, Characterization, and Performance Assessment of Nickel Macrocyclic Complexes. University Chemistry, 2024, 39(5): 163-171. doi: 10.3866/PKU.DXHX202310084
19. [19]
  Qingjun PAN , Zhongliang GONG , Yuwu ZHONG . Advances in modulation of the excited states of photofunctional iron complexes. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 45-58. doi: 10.11862/CJIC.20240365
20. [20]
  Linjie ZHU , Xufeng LIU . Electrocatalytic hydrogen evolution performance of tetra-iron complexes with bridging diphosphine ligands. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 321-328. doi: 10.11862/CJIC.20240207

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(325)
HTML views(52)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Structural Characterization and Artificial Nuclease Activity of Transition Metal Complexes of Cyclam Derivatives

References

Metrics

通讯作者: 陈斌, bchen63@163.com