Citation: LI Zhi-Xi, HU Ming, LIU Chao, YANG Xiao-Liang. Structural Characterization and Artificial Nuclease Activity of Transition Metal Complexes of Cyclam Derivatives[J]. Chinese Journal of Inorganic Chemistry, ;2015, (1): 127-132. doi: 10.11862/CJIC.2015.023 shu

Structural Characterization and Artificial Nuclease Activity of Transition Metal Complexes of Cyclam Derivatives

1.
State Key Laboratory of Coordination Chemistry, Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China

Corresponding author: YANG Xiao-Liang,
Received Date: 11 August 2014
Available Online: 24 October 2014
Fund Project: 国家自然科学基金(No.21131003)资助项目. (No.21131003)

Acyclam-based ligand: tetratert-butyl ((4,11-dimethyl^-1,4,8,11-tetraazacyclotetradecane^-1,8-diyl)bis (propane-3,2,1-triyl)) tetracarbamatev (L1), and its metal complexes [Zn(L₁)Cl₂] (1), [Ni(L₁)Cl₂] (2) and [Cu(L₁)Cl₂] (3) were designed and synthesized. L1 has a C₂ symmetrical structure and the ¹H chemical shift of the same carbon was different because of the influence of cyclam ring. The metal binding site of the L₁ was confirmed by 2D [¹H, ¹⁵N] HSQC by comparing the chemical shift of N of the branched chains of the ligand that of with the corresponding metal complex. The co-existence of two configuration was characterized by ¹³C VT NMR combined with 2D [¹H, ¹⁵N] HSQC NMR and trans-Ⅲ was confirmed to be the main configuration for complex 1. The cleavage activity of the ligand L₁ and the complexes 1~3 was investigated in detail under physiological conditions. Agarose gel electrophoresis experiments showed that the complex 3 possesses interesting nuclease activity in the present of ascorbate; No matter the hydrolysis or oxidation, the ligand L₁ and complex 1, and 2 were negative to DNA at the experimental conditions.
- cyclam derivatives;mono-metal complex;configuration;artificial nuclease
1. [1]
  [1] Hunter T M, Simpson D P, Smith A M, et al. Chem. Eur. J., 2007,13:40-50
2. [2]
  [2] Liang F, Wan S, Xiong X, et al. Curr. Med. Chem., 2006,13: 711-727
3. [3]
  [3] Ross A, Choi J H, Hunter T M, et al. Dalton Trans., 2012, 41:6408-6418
4. [4]
  [4] Canaple L, Husken, J H, et al. Bioconjugate Chem., 2002, 13:94-951
5. [5]
  [5] Korupoju S R, Mangayarkarasi N, Zacharias P S, et al. Inorg. Chem., 2002,41:4099-4101
6. [6]
  [6] Xia C Q, Jiang N, Zhang J, et al. Bioorg. Med. Chem., 2006, 14:5756-5764
7. [7]
  [7] Zhang Q, Xiang Y, Liang D W, et al. Bioorg. Med. Chem. Lett., 2012,22:1814-1817
8. [8]
  [8] Li C, Zhao F F, Huang Y N, et al. Bioconjugate Chem., 2012, 23:1832-1837
9. [9]
  [9] Joyner J C, Reichfield J, Cowan J A. J. Am. Chem. Soc., 2011,133:15613-15626
10. [10]
  [10] Sheng X, Guo X, Lu X M, et al. Bioconjugate Chem., 2008, 19:490-498
11. [11]
  [11] Ramalingam K, Raju N, Nanjappan P, et al. Tetrahedron, 1995,51:2875-2894
12. [12]
  [12] Kobelev S M, Averin A D, Buryak A K, et al. Hetercycles, 2011,82:1447-1476
13. [13]
  [13] Yu M F, Price J R, Jensen P, et al. Inorg. Chem., 2011,50: 12823-12835
14. [14]
  [14] Stephen J P, Sadler P J. Chem. Commun., 2004:306-307
15. [15]
  [15] Miyoshi T, Hayashi S, Imashiro F, et al. Macromolecules, 2002,35:2624-2632
16. [16]
  [16] Liang X Y, Weishaupl M, Parkinson J A, et al. Chem. Eur. J., 2003,9:4709-4717
17. [17]
  [17] (a)Molphy Z, Prisecaru A, Slator C, et al. Inorg. Chem., 2014,53:5392-5404 (b)Zhou W, Wang X Y, Hu M, et al. Chem. Sci., 2014,5: 2761-2770
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沈阳化工大学材料科学与工程学院沈阳 110142