Citation: QIU Lin, JI Yi-Fan, ZHU Cheng-Cheng, CHEN Yun-Cong, HE Wei-Jiang*, GUO Zi-Jian*. A BODIPY-Derived Zn²⁺ Fluorescent Sensor：the Enhanced ICT Effect[J]. Chinese Journal of Inorganic Chemistry, ;2014, 30(1): 169-178. doi: 10.11862/CJIC.2014.077 shu

A BODIPY-Derived Zn²⁺ Fluorescent Sensor：the Enhanced ICT Effect

1.
1 State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China;

Received Date: 27 October 2013
Available Online: 1 December 2013
Fund Project:

Modifying BODIPYwith a(4-hydroxyl)styryl group and a Zn²⁺ chelator respectively at α-and meso-positions resulted in a Zn²⁺ fluorescent sensor of yellow emission(580 nm) and large Stokes shift (~50 nm). The α-(4-hydroxyl)styryl-enhanced ICTeffect is responsible for the enlarged Stokes shift and bathochromic shifted excitation/emission of BODIPY, which favor to reduce the imaging interference of autofluorescence, phototoxicity and excitation. Photospectroscopic study disclosed the specific Zn²⁺-amplified fluorescence of this sensor, and the normal metal cations and near neutral pHshow very little interference to its Zn²⁺ sensing behavior. Its linear response range to Zn²⁺ is 0.12~1.2 μmol·L^-1, and the LOD is 0.18 μmol·L^-1. Confocal fluorescence imaging of intracellular Zn²⁺ in HeLa cells demonstrated the sensor's cell membrane permeability and its reversible cytosolic Zn²⁺ imaging ability.
- zinc;fluorescent sensor;ICT;cell;fluorescence imaging,
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

A BODIPY-Derived Zn2+ Fluorescent Sensor：the Enhanced ICT Effect

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通讯作者: 陈斌, bchen63@163.com

A BODIPY-Derived Zn²⁺ Fluorescent Sensor：the Enhanced ICT Effect