Citation: Wei Shuo FANG, Hong Yan LIU, Qi Cheng. Synthesis and Antitumor Activity of C-2/C-10 Modified Analogues of Docetaxel[J]. Chinese Chemical Letters, ;2005, 16(1): 38-40. shu

Synthesis and Antitumor Activity of C-2/C-10 Modified Analogues of Docetaxel

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050

Received Date: 11 December 2003

Fund Project: Financial support from Funding to Outstanding Doctor Thesis Authors of Chinese Universities (Grant No. 199949) is gratefully acknowledged by W. S. Fang.

Four 10-propionyl docetaxel analogues (11a-d) with 2α-amido substituents were prepared, and their antitumor activity against three solid tumor cell lines and their drug-resistant counterparts were determined.
- Paclitaxel,
- docetaxel,
- 2α-amido analogues,
- 10-propionate.
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