Citation: Yu Fei SONG, Hui Min ZHEN. Synthesis, and Investigation of the Reactive Oxygen Species of a Novel Cyclicpeptide-2,6-dimethoxyhydroquinone-3-mercaptoacetic Acid Conjugate[J]. Chinese Chemical Letters, ;2001, 12(12): 1075-1078. shu

Synthesis, and Investigation of the Reactive Oxygen Species of a Novel Cyclicpeptide-2,6-dimethoxyhydroquinone-3-mercaptoacetic Acid Conjugate

Yu Fei SONG ¹ ,
Hui Min ZHEN ²

1.
Institute of Molecular Science, Shanxi University, Taiyuan 030006;
2.
Taiyuan Teacher's College, Taiyuan 030006

Received Date: 20 April 2001

In this paper, we report the synthesis of a potential anti-cancer agent:Cyclo[Val-Lys(DMQ-MA)-Gaba]. The cytotoxic agent conjugated to the N-terminal and the ξ-amino group of lysine of the tripeptide is 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid (DMQ-MA). By employing the rhodamine B degradation method and ESR spectra, we testify the reactive oxygen species——hydroxyl radicals produced by the drug.
- 2,6-Dimethoxyhydroquinone-3-mercaptoacetic acid,
- cyclicpeptide
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