Citation: Wei LU, Guang Rong ZHENG, Da Xin GAO, Jun Chao CAI. Stereoselective Synthesis of 3(R) and 3(S)-Hydroxyeicos-4(E)-en-1-yne, a Component of the Marine Sponge Cribrochalina Vasculum[J]. Chinese Chemical Letters, ;1998, 9(4): 365-367. shu

Stereoselective Synthesis of 3(R) and 3(S)-Hydroxyeicos-4(E)-en-1-yne, a Component of the Marine Sponge Cribrochalina Vasculum

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031

Received Date: 11 December 1997

Fund Project: We thank the State Key Laboratory of Drug Research for financial support.

Stereocontrolled synthesis of 3(R) and 3(S)-hydroxyeicos-4(E)-en-1-yne has been achieved through double elimination of chloride intermediates 8 and 11,which were prepared from acetylenic alcohol intermediates 1 and 10.
- stereocontrolled synthesis,
- 3-hydroxyeicos-4(E)-en-1-yne,
- double elimination
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