Citation: Bing ZHENG, Jin Long WU, Shao Jun XU, Jian Feng SHI, Yao Zu CHEN. A Facile and Highly Stereoselective Reductive Debromination of Anhydro-6-(R)-Hydroxyethyl-6-Bromopenicillin[J]. Chinese Chemical Letters, ;2000, 11(5): 385-386. shu

A Facile and Highly Stereoselective Reductive Debromination of Anhydro-6-(R)-Hydroxyethyl-6-Bromopenicillin

a Department of Chemistry, Zhejiang University, Hangzhou 310027;
b National Laboratory of Applied Organic Chemistry, Lanzhou 730000

Received Date: 16 October 1999
Revised Date: 6 January 2000

Reductive debromination of anhydro-6-(R)-hydroxyethyl-6-bromopenicillin 7 by zinc in ammonium acetate gave 9 in 81% yield with high stereoselectivity of 6-(α):6-(β)=13:1.
- Reductive debromination,
- stereoselectivity,
- anhydro-6-(R)-hydroxyethyl-6-bromo-penicillin
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