Citation: Ai Qiao MI, Zeng Xin MA, Lan Jun WU, Yao Zhong JIANG. ASYMMETRIC SYNTHESIS Ⅻ:HIGHLY ENANTIOSELECTIVE SYNTHESIS OF α-AMINO ACIDS BY ALKYLATION OF THE KETIMINE FROM 2-HYDROXY-PINAN-3-ONE AND MENTHYL GLYCIN-ATE A DOUBLE ASYMMETRIC INDUCTION SYSTEM[J]. Chinese Chemical Letters, ;1991, 2(2): 115-118. shu

ASYMMETRIC SYNTHESIS Ⅻ:HIGHLY ENANTIOSELECTIVE SYNTHESIS OF α-AMINO ACIDS BY ALKYLATION OF THE KETIMINE FROM 2-HYDROXY-PINAN-3-ONE AND MENTHYL GLYCIN-ATE A DOUBLE ASYMMETRIC INDUCTION SYSTEM

Chengdu Institute of Organic Chemistry, Academia Sinica, Chengdu 610015

Received Date: 20 September 1990

Fund Project: This work was supported by the National Natural Science Fundation of China.

A series of α-amino acids are obtained in 72-96% optical yields by alkylation of the ketimine derived from (+)-2-hydroxy-pinan-3-one and (-)-menthyl glycinate followed by hydrolysis of the alkylated intermediates with mineral acid. The double asymmetric induction are explained by the transition model of lithium enolate.
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