Citation: Wang Ting, Cai Zhaosheng, Xu Qing. Progress in Preparation and Application of PEGylated Chitosans[J]. Chemistry, ;2020, 83(6): 536-545. shu

Progress in Preparation and Application of PEGylated Chitosans

Wang Ting ^1,2 ,
Cai Zhaosheng ^2,, ,
Xu Qing ^1,,

1.
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002
2.
School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, 224051

Corresponding author: Cai Zhaosheng, jsyc_czs@163.com Xu Qing, 6574394@qq.com
Received Date: 26 November 2019
Accepted Date: 2 January 2020

Figures(9)

Polyethylene glycol (PEG) is a non-toxic, lipophilic and hydrophilic compound which characterized with high biocompatibility and non-immunogenicity. Chitosan (CTS) can be transformed into PEGylated chitosan by introducing PEG into its sugar chain. It not only maintains the natural and excellent biodegradability of chitosan, but also has better water solubility and ability to bind organic compounds. The fields concerned with the application of CTS can be expanded through PEGylated modification. On basis of the relevant research traits in the past 20 years, the preparation of PEGylated chitosans and their application in the domains of drug loading and controlled release, tissue engineering, antibacterial materials, bioactive material delivery and environmental protection are summarized, and the future development trend is prospected.
- Chitosan,
- Polyethyleneglycol,
- Modification,
- Application
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