Citation: ZHOU Nianen, CHEN Qusheng, ZHUO Renxi. CHEMOTHERAPEUTIC POLYMER ⅩⅦ. THE SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYPHOSPHATES CONTAINING BOTH NUCLEIC ACID BASE AND NITROGEN MUSTARD[J]. Chinese Journal of Polymer Science, ;1986, 4(4): 316-321. shu

CHEMOTHERAPEUTIC POLYMER ⅩⅦ. THE SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYPHOSPHATES CONTAINING BOTH NUCLEIC ACID BASE AND NITROGEN MUSTARD

Received Date: 23 April 1985

Seven new polyphosphates containing both nucleic acid base and nitrogen mustard were preparedby reacting the monomers, i.e. 1,3-dihydroxyalkyl-5-fluorouracil(IIa.,b, g), 1,3-dihydroxyalkyluracil(IIc,d) and 1, 3-dihydroxyalkylthymine (IIe,f) with W, N,N-bis(2-chloroethyl)phosphoramide dichlo-ride (I). The monomers and polymers were characterized by 1H-NMR, IR spectra and elementalanalysis. All of the polymers obtained are soluble in water. The antitumor activity of some of thesepolymers were tested against Ehrlish Ascites in mice.The results showed that the polyphosphates containing both 5-fluorouracil and nitrogen mustard exhibit lower toxicity and higher antitumor activity.The inhibition ratio of the polymer(Ⅲa) is 66%.
1. [1]
  Guoping Yang , Zhoufu Lin , Xize Zhang , Jiawei Cao , Xuejiao Chen , Yufeng Liu , Xiaoling Lin , Ke Li . Assembly of Y(Ⅲ)-containing antimonotungstates induced by malic acid with catalytic activity for the synthesis of imidazoles. Chinese Chemical Letters, 2024, 35(12): 110274-. doi: 10.1016/j.cclet.2024.110274
2. [2]
  Chen Lian , Si-Han Zhao , Hai-Lou Li , Xinhua Cao . A giant Ce-containing poly(tungstobismuthate): Synthesis, structure and catalytic performance for the decontamination of a sulfur mustard simulant. Chinese Chemical Letters, 2024, 35(10): 109343-. doi: 10.1016/j.cclet.2023.109343
3. [3]
  Liying Ou , Zhenluan Xue , Bo Li , Zhiwei Jin , Jiaochan Zhong , Lixia Yang , Penghui Shao , Shenglian Luo . Nitrogen-containing linkage-bonds in covalent organic frameworks: Synthesis and applications. Chinese Chemical Letters, 2025, 36(6): 110294-. doi: 10.1016/j.cclet.2024.110294
4. [4]
  Jing LIANG , Qian WANG , Junfeng BAI . Synthesis and structures of cdq-topological quaternary and (4, 4, 8)-c topological quinary Zn-MOFs with both oxalic acid and triazole ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(11): 2186-2192. doi: 10.11862/CJIC.20240177
5. [5]
  Maitri Bhattacharjee , Rekha Boruah Smriti , R. N. Dutta Purkayastha , Waldemar Maniukiewicz , Shubhamoy Chowdhury , Debasish Maiti , Tamanna Akhtar . Synthesis, structural characterization, bio-activity, and density functional theory calculation on Cu(Ⅱ) complexes with hydrazone-based Schiff base ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1409-1422. doi: 10.11862/CJIC.20240007
6. [6]
  Jing Guo , Zhi-Guo Lu , Rui-Chen Zhao , Bao-Ku Li , Xin Zhang . Nucleic acid therapy for metabolic-related diseases. Chinese Chemical Letters, 2025, 36(3): 109875-. doi: 10.1016/j.cclet.2024.109875
7. [7]
  Jialin Guo , Mingrui Gu , Yahui Chen , Tao Xiong , Yiyang Zhang , Simin Chen , Mingle Li , Xiaoqiang Chen , Xiaojun Peng . Nucleic acid delivery by lipid nanoparticles for organ targeting. Chinese Chemical Letters, 2025, 36(11): 110849-. doi: 10.1016/j.cclet.2025.110849
8. [8]
  Yuanfei Liu , Wanjiao Wei , Xu Liu , Rui Hua , Yanjuan Liu , Yuefei Zhang , Wei Chen , Sheng Tang . Green and mild synthesis of Ca-MOF/COF functionalized silica microspheres in an acid-base tunable deep eutectic solvent for multi-mode chromatography. Chinese Chemical Letters, 2026, 37(1): 111186-. doi: 10.1016/j.cclet.2025.111186
9. [9]
  Zhi-Lin Wu , Rong-Nan Yi , Chunlin Zhuang . Electrochemical synthesis strategy for the development of antitumor selenoheterocyclic compounds. Chinese Chemical Letters, 2025, 36(10): 111408-. doi: 10.1016/j.cclet.2025.111408
10. [10]
  Di ZHANG , Tianxiang XIE , Xu HE , Wanyu WEI , Qi FAN , Jie QIAO , Gang JIN , Ningbo LI . Construction and antitumor activity of pH/GSH dual-responsive magnetic nanodrug. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 786-796. doi: 10.11862/CJIC.20240329
11. [11]
  Lihang Wang , Mary Li Javier , Chunshan Luo , Tingsheng Lu , Shudan Yao , Bing Qiu , Yun Wang , Yunfeng Lin . Research advances of tetrahedral framework nucleic acid-based systems in biomedicine. Chinese Chemical Letters, 2024, 35(11): 109591-. doi: 10.1016/j.cclet.2024.109591
12. [12]
  Qijun Tang , Wenguang Tu , Zhigang Zou . Solar-driven methane-to-ethanol conversion by “intramolecular junction” with both high activity and selectivity. Chinese Journal of Structural Chemistry, 2025, 44(6): 100597-100597. doi: 10.1016/j.cjsc.2025.100597
13. [13]
  Dexuan Xiao , Tianyu Chen , Tianxu Zhang , Sirong Shi , Mei Zhang , Xin Qin , Yunkun Liu , Longjiang Li , Yunfeng Lin . Transdermal treatment for malignant melanoma by aptamer-modified tetrahedral framework nucleic acid delivery of vemurafenib. Chinese Chemical Letters, 2024, 35(4): 108602-. doi: 10.1016/j.cclet.2023.108602
14. [14]
  Tao Yu , Vadim A. Soloshonok , Zhekai Xiao , Hong Liu , Jiang Wang . Probing the dynamic thermodynamic resolution and biological activity of Cu(Ⅱ) and Pd(Ⅱ) complexes with Schiff base ligand derived from proline. Chinese Chemical Letters, 2024, 35(4): 108901-. doi: 10.1016/j.cclet.2023.108901
15. [15]
  Yingyue ZHANG , Liuqing KANG , Yating YANG , Xiaofen GUAN , Wenmin WANG . Crystal structure and antibacterial activity of two Gd₂ complexes based on polydentate Schiff-base ligands. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1867-1877. doi: 10.11862/CJIC.20250100
16. [16]
  Chengcheng Zhang , Zhe Wu , Ningning Jiang , Yi Song , Weina Geng , Hongmei Liu , Ming Jin , Shuxiang Wang , Jinchao Zhang , Yutao Yang . A fluorescent probe regulated by trifluoromethyl and nitrogen-containing heterocycles for monitoring biothiol fluctuations in the brains of mice with schizophrenia. Chinese Chemical Letters, 2026, 37(1): 111476-. doi: 10.1016/j.cclet.2025.111476
17. [17]
  Ruofan Qi , Jing Zhang , Wang Sun , Bai Yu , Zhenhua Wang , Kening Sun . Solid-acid-Lewis-base interaction accelerates lithium ion transport for uniform lithium deposition. Chinese Chemical Letters, 2025, 36(6): 110009-. doi: 10.1016/j.cclet.2024.110009
18. [18]
  Kai Wang , Yun Wang , Lihang Wang , Zhuhai Li , Xi Yu , Xuanhe You , Diwei Wu , Yueming Song , Jiancheng Zeng , Zongke Zhou , Shishu Huang , Yunfeng Lin . Therapeutic siRNA targeting CC chemokine receptor 2 loaded with tetrahedral framework nucleic acid alleviates neuropathic pain by regulating microglial polarization. Chinese Chemical Letters, 2025, 36(3): 109868-. doi: 10.1016/j.cclet.2024.109868
19. [19]
  Fengqing Wang , Changxing Qi , Chunmei Chen , Qin Li , Qingyi Tong , Weiguang Sun , Zhengxi Hu , Minyan Wang , Hucheng Zhu , Lianghu Gu , Yonghui Zhang . Discovery and enantioselective total synthesis of antitumor agent asperfilasin A via a regio- and diastereoselective Nazarov cyclization. Chinese Chemical Letters, 2025, 36(6): 110252-. doi: 10.1016/j.cclet.2024.110252
20. [20]
  Yuanping Jiang , Haoqi Liu , Jiawei Zhang , Luying Jiao , Xiaoling Lin , Fuhua Zhang , Guoping Yang . Four tartaric acid-bridged tetra-europium(III)-containing antimonotungstate with catalytic oxidation of thioethers/alcohols. Chinese Journal of Structural Chemistry, 2025, 44(7): 100603-100603. doi: 10.1016/j.cjsc.2025.100603

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(1120)
HTML views(17)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return