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Citation: Wan Lingzi, Wang Han. Research Progress in Drugs Containing Cyclopropyl Group[J]. Chemistry, ;2019, 82(11): 963-971. shu

Research Progress in Drugs Containing Cyclopropyl Group

Wan Lingzi ,
Wang Han ^,

Shanghai University of Engineering Science, Shanghai 201620

Corresponding author: Wang Han, wanghan@sues.edu.cn
Received Date: 6 July 2019
Accepted Date: 18 August 2019

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The chemical structure of cyclopropyl is different from straight-chain aliphatic hydrocarbons or other poly-aliphatic rings. It is often used in the design of drugs. It can increase the efficacy of drugs, enhance the metabolic stability, reduce the miss distance function, enhance receptor affinity, limit the ability of peptide hydrolysis, increase blood brain barrier permeability, reduce plasma clearance and improve the degree of dissociation of the drug (pK_a). Drugs with cyclopropyl group have been developed to treat respiratory diseases, mental disorders, endocrine and metabolic diseases, infectious diseases, neurological diseases, cardiovascular and cerebrovascular diseases, and tumors. The research progress in drugs with cyclopropyl structure is reviewed in this paper.
- Cyclopropyl,
- Infectious diseases,
- Cardiovascular and cerebro-vascular diseases
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