Citation: Qi Liang DENG, Zhi Hong LUN, Chao YAN, Ru Yu GAO. Preparation and Evaluation of Molecularly Imprinted Monolithic Column for Felodipine in Micro-liquid Chromatography[J]. Chinese Chemical Letters, ;2005, 16(7): 955-958. shu

Preparation and Evaluation of Molecularly Imprinted Monolithic Column for Felodipine in Micro-liquid Chromatography

1.
State Key Laboratory of Element Organic Chemistry, Institute of Element Organic Chemistry, Nankai University, Tianjin 300071;
2.
The School of Science, University of Science and Technology of Tianjin, Tianjin 300222;
3.
Unimicro Technologies Inc., 4713 First Street, Pleasanton, CA 94566, USA

Received Date: 23 August 2004

Fund Project: This work was supported by the National Natural Science Foundation of China (20175010).

This study concentrated on the production of molecularly imprinted polymers (MIPs) as highly selective sorbents for felodipine (FLD), a representive dihydropyridine calcium antagonists.Demonstrated chromatographically through a selection factor, these MIPs showed high selectivity for the template molecule among a group of structurally similar compounds. The recognition was found to correlate with structural similarity to the template compound.
- Molecularly Imprinted polymers,
- felodipine
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