Citation: Xin CHEN, Jin Sheng ZHANG, Ming ZHAO. Synthesis of Novel Diterpenequinone Salvicine from Ferruginol[J]. Chinese Chemical Letters, ;2001, 12(4): 297-300. shu

Synthesis of Novel Diterpenequinone Salvicine from Ferruginol

Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031

Received Date: 27 September 2000

Fund Project: This work was supported by a grant for "1035" Major Project of New Drugs from the Ministry of Science and Technology of China (No.969010104) and a grant for "95" Major Research Project of Natural Resources and Environment, Chinese Academy of Sciences (No.KY95T0605).

An efficient synthetic route has developed to the antitumor compound salvicine via 9 steps from ferruginol. The key reaction is the rearrangement of the angular methyl group of compound 7 to 4,5-seco-5,10,-friedo-abieta diterpene 8.
- Synthesis,
- rearrangement,
- ferruginol,
- salvicine.
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