Citation: Yun Hai ZHANG, Lin Xiang ZHAO, Zhen Jun BIAN, Rui WANG, Fu Yuan SUN. Synthesis of 2-Heterocyclomethyl-5-diphenylmethylenecyclopentanone Hydrochlorides and their Inhibitory Effect on Tumor Cell Growth[J]. Chinese Chemical Letters, ;2006, 17(9): 1181-1184. shu

Synthesis of 2-Heterocyclomethyl-5-diphenylmethylenecyclopentanone Hydrochlorides and their Inhibitory Effect on Tumor Cell Growth

School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016

Received Date: 20 March 2006

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 30171099).

Sixteen new 2-heterocyclomethyl-5-diphenylmethylenecyclopentanone hydrochlorides were designed and synthesized. The growth inhibitory effect of these compounds in vitro was conducted using a MTT assay in human breast cancer T47D cells.
- Cyclopentanone,
- synthesis,
- growth inhibition
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