Citation: Yuan Liu WU, Max TISHLER. SYNTHESIS OF α-AMINO-β-(4-IMIDAZOLYL)-ETHYLPHOSPHONIC ACID,THE PHOSPHONOISOSTERE OF HISTIDINE[J]. Chinese Chemical Letters, ;1991, 2(2): 95-98. shu

SYNTHESIS OF α-AMINO-β-(4-IMIDAZOLYL)-ETHYLPHOSPHONIC ACID,THE PHOSPHONOISOSTERE OF HISTIDINE

Yuan Liu WU ^a ,
Max TISHLER ^b

a Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050;
b Hall-Atwater Laboratories, Department of Chemistry, Wesleyan University, Middletown, Conn. 06457, USA

Received Date: 29 June 1990

A short synthesis starting from 4-imidazolylmethanol (2) was developed for the phosphonoisostere of histidine, α-amino-β-(4-imidazolyl)-ethylphosphosphonic acid, His (P) (1). The synthesis features Wittig-Horner reaction of aldehyde (4) with diphosphonate (5) followed by selective detritylation with 50% formic acid.
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