Citation: Jing Xu GONG, Lin Jia WENG, Feng WANG, Yu Bin FENG, Chang Xin ZHOU, Hai Bo LI, Yi Hang WU, Xiao Jiang HAO, Xiu Mei WU, Hua BAI, Joachim STÖCKIGT, Yu ZHAO. Synthesis and Antioxidant Properties of Novel Silybin Analogues[J]. Chinese Chemical Letters, ;2006, 17(4): 465-468. shu

Synthesis and Antioxidant Properties of Novel Silybin Analogues

1.
Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031;
2.
The Key Laboratory of Chemistry of Natural Products of Guizhou Province, Chinese Academy of Sciences, Guiyang 550022;
3.
Zhejiang Hisun Naturelite Pharmaceutical R & D Co., Ltd., Hangzhou 310007;
4.
Lehrstuhl für Pharmazeutische Biologie, Institut für Pharmazie, Johannes-Gutenberg Universität Mainz, D-55099 Mainz, Germany

Received Date: 19 September 2005

Eight novel silybin analogues (7a-h) were synthesized and their antioxidant properties including the capability of scavenging superoxide anion free radicals and the inhibitory effect on DPPH free radicals were determined. Several synthetic compounds showed comparable antioxidative effect to that of quercetin.
- Silybin analogues,
- synthesis,
- antioxidant,
- DPPH inhibition,
- superoxide anion free radical scavenging
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