Citation: Hui Lan CHEN, Hong YAN, Wen Xia TANG. AN IMPROVED METHOD TO SYNTHESIZE VITAMIN B₁₂ COENZYME ANALOGUES CONTAINING 2'-DEOXYNUCLEOSIDE[J]. Chinese Chemical Letters, ;1992, 3(4): 245-246. shu

AN IMPROVED METHOD TO SYNTHESIZE VITAMIN B₁₂ COENZYME ANALOGUES CONTAINING 2'-DEOXYNUCLEOSIDE

Department of Chemistry and Coordination Chemistry Institute Nanjing University Nanjing 210008

Received Date: 5 December 1991

A new vitamin B₁₂ coenzyme analogue 2’,5’-dideoxyuridinyicobalamin and two other 2’,5’-dideoxynucleosidecobalamins of adenosyl-and thymidyl-were synthesized by an improved method, It consists in direct tosylation of the nucleoside and followed by reaction with reduced hydroxocobalamin(vitamin B₁₂). All the 2’-deozynucleoside derivatives were characterized by UV-Vis and ¹HNMR spectroscopy
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