Citation: Ru Yu CHEN, Jian Wu WANG, Jing Jiang LIU, Gui Lin DUAN. A STUDY ON THE SELECTIVE REDUCTION OF AROMATIC AMIDE WITH LiAlH₄[J]. Chinese Chemical Letters, ;1991, 2(4): 269-272. shu

A STUDY ON THE SELECTIVE REDUCTION OF AROMATIC AMIDE WITH LiAlH₄

1.
The Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071;
2.
The Chemistry Department of Nankai University, Tianjin, 300071

Received Date: 11 January 1991

Fund Project: Project supported by National Natural Science Foundation of China.

In the synthesis of l-phenyl-5-substituted amino-4-pyrazole N-alkyl amide,it was found for the first time that one of the two aromatic amido groups in the molecule of 1-phenyl-5-benzoyl amino-4-pyrazole N-alkyl amide was reduced selectively by LiAlH₄.A new conclusion was drawn after several experiments have been done that ortho-amino(or substituted amino)aryl amide or the aryl amide with its ortho substituent which can be reduced into an amino group(or substituted amino group)can not be reduced by LiAlH₄.It was further rationalized by quantum chemical calculation.
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