Citation: Miao WANG, Jian Wei YAN, Yan Fei LIN, Jian De LU, Xiao Yun FU. Effect of Micelle Composition on Acidic Drugs Separation Behavior by Micellar Electrokinetic Capillary Chromatography[J]. Chinese Chemical Letters, ;2002, 13(12): 1203-1204. shu

Effect of Micelle Composition on Acidic Drugs Separation Behavior by Micellar Electrokinetic Capillary Chromatography

1.
Department of Chemistry, Yuquan Campus, Zhejiang University, Hangzhou 310027;
2.
Zhejiang College of Chinese Traditional Medicine, Hangzhou 310053

Received Date: 1 April 2002

Micellar electrokinetic capillary chromatography (MECC) separation of four acidic drugs similar in structure was studied. Both anionic surfactant sodium dodecyl sulfate (SDS) and nonionic surfactant Tween 20 were used to form single micelles and mixed micelles as pseudostationary phases. The effects of the composition of micellar solution on retention behaviors were studied. The results indicate that there is markedly different selectivity among SDS, Tween 20 and the mixed micelles systems.
- Micelle,
- electrokinetic chromatography,
- acidic drug
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