Citation: Xu Chang HE, Zhen Rong XU, Yun Long LI, Zhao Ying WANG, Dong Lu BAI. SYNTHESIS OF ANALOGUES OF HUPERZINE A 2. The Preparation of Some Analogues with Huperzine A Skeleton[J]. Chinese Chemical Letters, ;1994, 5(6): 471-474. shu

SYNTHESIS OF ANALOGUES OF HUPERZINE A 2. The Preparation of Some Analogues with Huperzine A Skeleton

Shanghai Institute of Materia Medica Chinese Academy of Sciences, 294 Tai-yuan Road Shanghai 20031

Received Date: 9 March 1994

Huperzine A (1),a new Lycopodium alkaloid isolated from Chinese traditional medicine Huperzia Serrata,is a potent acetylcholinesterase inhibitor and a promising drug candidate of treating Alzheimer's disease as well.Several analogues of huperzine A,compound 8,10,14,15 and 17 were prepared and their inhibitory activities of acetylcholinesterase were evaluated.
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