Citation: Guo Juan LIANG, Jin Zhong ZHANG, An Qi CHEN. β-Lactam Templated Macrocyclization:Synthesis of 12-Membered Macrolide[J]. Chinese Chemical Letters, ;2005, 16(5): 601-603. shu

β-Lactam Templated Macrocyclization:Synthesis of 12-Membered Macrolide

Department of Chemistry, Xiamen University & The Key Laboratory for Chemical Biology of Fujian Province, Xiamen 361005

Received Date: 9 May 2004

Fund Project: This work is supported by the National Natural Science Foundation of China (grant No:20372056) and a Research Fund from the Royal Society of Chemistry, UK.

A novel macrolactonization method was developed using a chiral β-lactam as the template. This novel method features that the macrocyclization is simultaneously achieved while a TBS protected hydroxy group is deprotected.
- β-Lactam,
- macrolactonization,
- macrolide,
- templated cyclization
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