Citation: Bin SU, Hui LI, Meng Shen CAI, Zhong Jun LI. On the Mechanism of Condensation between 5-Amino-4, 6-dichloro-2-methylpyrimidine and 1-Acetyl-2-imidazolin-2-one[J]. Chinese Chemical Letters, ;2002, 13(3): 207-210. shu

On the Mechanism of Condensation between 5-Amino-4, 6-dichloro-2-methylpyrimidine and 1-Acetyl-2-imidazolin-2-one

Department of Chemical Biology, School of Pharmaceutical science, Peking University, Beijing 100083

Received Date: 15 June 2001

The condensation reaction between 5-amino-4, 6-dichloro-2-methylpyrimidine and 1-acetyl-2-imidazolin-2-one using POCl₃ as solvent gave 4, 6-dichloro-2-methyl-5-(l-acetyl-tetrahydro-imidazo-2-ylidene)-aminopyrimidine predominantly and 4, 6-dichloro-2-methyl-5-{1-[ l-(2-oxo-tetrahydro-imidazolyl)]-acetyene}-aminopyrimidine as by-product. No 4, 6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine was found. The result indicated an esterifi-cation-addition-elimination mechanism.
- Moxonidine,
- X-ray single crystal diffiaction,
- GHMBC
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