Citation: Yan He HUANG, De Quan YU. Total Synthesis of dl-Ligustiphenol[J]. Chinese Chemical Letters, ;1996, 7(10): 896-897. shu

Total Synthesis of dl-Ligustiphenol

Yan He HUANG ,
De Quan YU

Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050

Received Date: 3 May 1996

—(-)S-Ligustiphenol is a new sesquiterpene compound with antiinflammatory and immunosuppressive activities.The total synthesis of its racemate was carried out by a six-step reaction sequence including bromination of aldehyde, iodination of m-cresol, protection of phenolic hydroxyl, Grignard reaction, aldol condensation, etc.The target compound was characterized by comparing its ¹H NMR, MS and IR spectra with natural (-) ligustiphenol.
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