Citation: De Xin WANG, Ying SUN, Gui Shen LU, Qing Chai Xu. DICHLORODIMETHYLSILANE-A USEFUL REAGENT FOR THE CLEAVAGE OF PEPTIDYL WANG RESIN[J]. Chinese Chemical Letters, ;1994, 5(7): 581-584. shu

DICHLORODIMETHYLSILANE-A USEFUL REAGENT FOR THE CLEAVAGE OF PEPTIDYL WANG RESIN

Institute of Materia Medica, Chinese Academy of Medical science, 100050 Beijing

Received Date: 12 April 1994

Fund Project: This study constitute a portion from project of studies on structural modification and bioactivity of hF-GRP and its analogs, which was supported by the National Natural Science Foundation of China, No. 3907951.

In present study,an organic compound,DDSi,was found to cleave peptidyl Wang-resin linker efficiently.The yields and purities of free peptides were comparable with products released by TFA,the conventional procedure.
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