Citation: Shuo De ZHANG, Gang LIU, Su Quan XIA. Design and Solid-Phase Synthesis of Multiple Muramyl Dipeptide (MMD)[J]. Chinese Chemical Letters, ;2001, 12(10): 887-888. shu

Design and Solid-Phase Synthesis of Multiple Muramyl Dipeptide (MMD)

1.
Beijing Institute of Pharmacology and Toxicology, Beijing 100850;
2.
Institute of Materia Medica, Chinese Academy of Medical Sciences and Perking Union Medical College, Beijing 100050

Received Date: 26 March 2001

Fund Project: These studies were granted by the National Natural Science Foundation of China (39600183).

As a non-specific modulator of macrophage, multiplied muramyl dipeptide (MMD) is solid-phase synthesized by application of standard Fmoc chemistry strategy. Tam's multiple antigen system (MAS) is used as our four branched-linker on Lysine.
- Multiplied muramyl dipeptide,
- multiple antigen system,
- macrophage,
- solid-phase synthesis
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