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Citation:
Ye WANG, Yan Li ZHOU, Zhan Zhu LIU, Shi Zhi CHEN, Xiao Guang CHEN. Synthesis and Antitumor Activity of an Analog of Phthalascidin[J]. Chinese Chemical Letters,
;2006, 17(10): 1279-1282.
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An analog of phthalascidin (Pt-650) was synthesized with an improved synthetic route.With precursor 2 as the starting material, compound 1 was prepared through 4 steps in a total yield of 47%. In vitro antitumor test of this Pt-650 analog showed that it possessed strong toxicity against a number of tumor cell lines including A2780, A549, Bel-7402, BGC-823, HELA, KB,KeTr3 and HCT-8.
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Keywords:
- Ecteinascidin,
- phthalascidin,
- tetrahydroisoquinoline,
- antitumor
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