Citation: Zhi Jie XUE, Yuan Chao LI. Synthesis and Determination of Absolute Configuration of a Divergent Polyhydroxy Enyne Compound[J]. Chinese Chemical Letters, ;2005, 16(12): 1569-1572. shu

Synthesis and Determination of Absolute Configuration of a Divergent Polyhydroxy Enyne Compound

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203

Received Date: 21 March 2005

Polyhydroxy enyne compound (+)-(1'S, 2R, 3S, 5S, 6S)-5,6-dimethoxy-5, 6-dimethyl-2-(1'-hydroxylpropyl-2-ne)-3-vinyl-1,4-dioxane has been synthesized from D-(-)-tartaric acid. A new chiral center was established by nucleophilic addition with 87% de. The modified Mosher's method was employed to confirm the absolute configuration of 17, which assigned the S-configuration at the new chiral center.
- Tartaric acid,
- enyne compound,
- nucleophilic addition,
- modified Mosher's method
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