Citation: Wang Jianguo, Li Chunbin, Jiang Guoyu. Progress in Fluorescent Probes for Aminopeptidase N[J]. Chemistry, ;2018, 81(11): 972-980. shu

Progress in Fluorescent Probes for Aminopeptidase N

Gannan Normal University, Key Laboratory of Organo-pharmaceutical Chemistry, Ganzhou 341000

Corresponding author: Jiang Guoyu, jiangguoyu@mail.ipc.ac.cn
Received Date: 4 July 2018
Accepted Date: 6 August 2018

Figures(11)

Aminopeptidase N (APN) is an exopeptidase that widely exists in the body of mammals. It is recognized to have various physiological functions in human body. Herein, the development of fluorescent probes for aminopeptides N was reviewed and generally divided into two categories:affinity based fluorescent probes and reaction based fluorescent probes, with their advantages and shortcomings compared, which may illuminate the future development of APN fluorescent probes.
- Aminopeptidase N,
- Fluorescent probe,
- Affinity based probes,
- Reaction based probes
1. [1]
  Y P Luan, W F Xu. Curr. Med. Chem., 2007, 14(6): 639~647.
2. [2]
  B Bauvois, D Dauzonne. Med. Res. Rev., 2006, 26(1): 88~130.
3. [3]
  P Mina-Osorio. Trends Mol. Med., 2008, 14(8): 361~371.
4. [4]
  B Holdt-Lehmann, A Lehmann, G Korten et al. Clin. Chim. Acta, 2000, 297(1): 93~102.
5. [5]
  S X Cui, X J Qu, Z H Gao et al. Cancer Lett., 2010, 292(2): 153~162.
6. [6]
  D Fontijn, M C Duyndam, M P van Berkel et al. Br. J. Cancer, 2006, 94(11): 1627~1636.
7. [7]
  T Tokuhara, N Hattori, H Ishida et al. Clin. Cancer Res., 2006, 12(13): 3971~3978.
8. [8]
  C Mawrin, C Wolke, D Haase et al. Brain Pathol., 2010, 20(1): 200~210.
9. [9]
  N Petrovic, W Schacke, J R Gahagan et al. Blood, 2007, 110(1): 142~150.
10. [10]
  M Terauchi, H Kajiyama, K Shibata et al. BMC Cancer, 2007, 7(1): 140~153.
11. [11]
  P Mina-Osorio. Trends Mol. Med., 2008, 14(8): 361~371.
12. [12]
  X C Gao, R X Cui, G F Ji et al. Nanoscale, 2018, 10(13): 6205~6211.
13. [13]
  Y Z Chen, X M Shi, Z L Lu et al. Anal. Chem., 2017, 89(10): 5278~5284.
14. [14]
  J G Wang, X G Gu, P F Zhang et al. J. Am. Chem. Soc., 2017, 139(46): 16974~16979.
15. [15]
  G Y Jiang, G J Zeng, W P Zhu et al. Chem. Commun., 2017, 53(32): 4505~4508.
16. [16]
  F Hu, Y Y Huang, G X Zhang et al. Anal. Chem., 2014, 86(15): 7987~7995.
17. [17]
  X G Gu, G X Zhang, D Q Zhang, Analyst, 2012, 137(2): 365~369.
18. [18]
  L Z Chen, J J Mou, Y Y Xu et al. Drug Discov. Ther., 2011, 5(2): 61~65.
19. [19]
  Y Ma, Q Y Tang, J Zhu et al. Chin. Chem. Lett., 2014, 25(5): 680~686.
20. [20]
  Z E Zhang, H Harada, K Tanabe et al. Peptides, 2005, 26(11): 2182~2187.
21. [21]
  A von Wallbrunn, J Waldeck, C H ltke et al. J. Biomed. Opt., 2008, 13(1): 011007.
22. [22]
  A H Negussie, J L Miller, G Reddy et al. J. Control. Release, 2010, 143(2): 265~273.
23. [23]
  Y Tang, A Shao, J Cao et al. Sci China Chem., 2018, 61(2): 184~191.
24. [24]
  Y Zhang, W Xu, L Kong et al. Mater. Chem. Front., 2018, DOI: 10.1039/C8QM00235E.
25. [25]
  X Gu, X Zhang, H Ma et al. Adv. Mater., 2018, DOI: 10.1002/adma.201801065.
26. [26]
  X Gu, E Zhao, T Zhao et al. Adv. Mater., 2016, 28(25): 5064~5071.
27. [27]
  X Gu, E Zhao, J W Y Lam et al. Adv. Mater., 2015, 27(44): 7093~7100.
28. [28]
  X Gu, R T K Kwok, J W Y Lam et al. Biomaterials, 2017, 146: 115~135.
29. [29]
  Y Cheng, C L Sun, X W Ou et al. Chem. Sci., 2017, 8(6): 4571~4578.
30. [30]
  W Xu, Q Li. Curr. Med. Chem., 2005, 5(3): 281~301.
31. [31]
  H Chen, H Wang, X J Qin et al. Chin. Chem. Lett., 2015, 26(5): 513~516.
32. [32]
  A Hahnenkamp, M Schäfers, C Bremer et al. Bioconjugate Chem., 2013, 24(6): 1027~1038.
33. [33]
  L Chen, W Sun, W Li et al. Anal. Methods, 2012, 4(9): 2661~2663.
34. [34]
  L Chen, W Sun, J Li et al. Org. Biomol. Chem., 2012, 11(2): 378~382.
35. [35]
  J Li, L Chen, W Wu et al. Anal. Chem., 2014, 86(5): 2747~2751.
36. [36]
  X He, Y Xu, W Shi et al. Anal. Chem., 2017, 89(5): 3217~3221.
37. [37]
  X He, Y Hu, W Shi et al. Chem. Commun., 2017, 53(68): 9438~9441.
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