Citation: Xing ZHENG, Jian Guo CAO, Duan Fang LIAO, Bing Yang ZHU, Hui Ting LIU. Synthesis and Anticancer Effect of gem-Difluoromethylenated Chrysin Derivatives[J]. Chinese Chemical Letters, ;2006, 17(11): 1439-1442. shu

Synthesis and Anticancer Effect of gem-Difluoromethylenated Chrysin Derivatives

1.
Institute of Pharmacy & Pharmacology, Nanhua University, Hengyang 421001;
2.
Cancer Research Institute, Nanhua University, Hengyang 421001

Received Date: 31 August 2006

Fund Project: This research was supported by Scientific Research Fund of Hunan Provincial Education Department (No. 04C555).

Ten gem-difluoromethylenated chrysin derivatives were prepared and their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of gem-difiuoromethylenated chrysin derivatives had higher anticancer activity than chrysin.
- Anticancer activity,
- gem-difluoromethylenated,
- chrysin
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