Citation: Jun Zhu, Chang-wang Pan, Ling Tong, Han Yan, Jian Shen, Si-cong Lin. Improving Nonthrombogenicity of Chitin with Zwitterionic Structure of Sulfobetaine[J]. Chinese Journal of Polymer Science, ;2005, 23(4): 449-452. shu

Improving Nonthrombogenicity of Chitin with Zwitterionic Structure of Sulfobetaine

Corresponding author: Si-cong Lin,
Received Date: 5 August 2004
Revised Date: 5 January 2005

In order to improve the nonthrombogenicity of chitin, a new monomer, N, N-dimethyl(b-hydroxyethyloxyethyl) ammonium propanesulfonate (DHAPS) was designed, synthesized and grafted onto the chitin membrane by using hexamethylene diisocyanate (HDI) as a coupling agent. Surface analysis of the grafted membranes by ATR-FTIR and XPS confirms that DHAPS has been successfully grafted onto the membrane surface. The platelet resistant property of the grafted membranes was evaluated by a platelet-rich plasma adhesion method. The results showed that platelet-adhesive resistance of the modified membrane has been greatly improved.
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