Citation: Zhang Yimin, Xu Jingna, Bai Jiarui. Microwave-Assisted Synthesis and Characterations of Sulfobutyl Ether β-Cyclodextrins[J]. Chemistry, ;2017, 80(6): 585-588, 572. shu

Microwave-Assisted Synthesis and Characterations of Sulfobutyl Ether β-Cyclodextrins

Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering & Technology, Collaborative Innovation Center of Chemical Science and Engineeing(Tianjin), Tianjin University, Tianjin 300350

Received Date: 22 October 2016
Accepted Date: 3 January 2017

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A novel process for microwave-assisted synthesis of sulfobutyl ether-β-cyclodextrins was investigated through reaction between β-cyclodextrin and 1, 4-butane sultone with adding the alkali stepwise. The effects of initial amount of alkali on the degree of substitution were evaluated. Under the synthesis conditions:the molar ratios of 1, 4-butane sultone and β-cyclodextrin are 1:1.2, 1:5, 1:8, respectively, the reaction temperature is 85℃, microwave output power is 400 W, and the reaction time is 2~3h, the average degrees of substitution of products are 1.12, 3.96, 6.83, and the yield of sulfobutyl ether β-cyclodextrin derivatives is up to 86.3%, 85.6%, 85.1%, respectively. The average degree of substitution and the characterizations of sulfobutyl ether β-cyclodextrin derivatives were investigated by means of IR, ¹H NMR, MS and capillary electrophoresis. The experimental results showed that, compared with the conventional heating process, the novel process for the synthesis of sulfobutyl ether β-cyclodextrins with specific average degree of substitution has the advantages of shorter reaction time, less alkali, milder reaction conditions, etc.
- β-cyclodextrin,
- 1, 4-butane sultone,
- Sulfobutyl ether-β-cyclodextrins,
- Microwave radiation
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