Citation: Qiang JIA, Zheng Ming LI, Su Hua WANG, Wei Guang ZHAO, You Ming WANG. No-solvent Condensation Reaction of Amino Acids and their Derivatives with Pyrandione[J]. Chinese Chemical Letters, ;2001, 12(6): 475-476. shu

No-solvent Condensation Reaction of Amino Acids and their Derivatives with Pyrandione

Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071

Received Date: 31 October 2000

Fund Project: We thank the National Natural Science Foundation of China for the project support (No.29832050) and Prof. Yu Fen HAN for her helpful bioassay.

Synthesis of a novel series of N-pyrandione substituted amino acids and their esters 3 via a condensation reaction between pyrandione and amino acid or their derivatives in excess ethyl orthoformate without solvent is described. The stereochemistry of 3 has been discussed.
- Pyrandione,
- amino acid,
- condensation reaction,
- Z/E isomer,
- green chemistry.
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