Citation: Guo Qiang HU, Zhong Quan ZHANG, Wen Long HUANG, Hui Bin ZHANG, Sheng Tang HUANG. Synthesis and Antibacterial Activity of New Tetracyclic Triazolothiadiazino Fluoroquinolones[J]. Chinese Chemical Letters, ;2004, 15(1): 23-25. shu

Synthesis and Antibacterial Activity of New Tetracyclic Triazolothiadiazino Fluoroquinolones

1.
Medical College of Henan University, Kaifeng 475004;
2.
China Pharmaceutical University, Nanjing 210009

Received Date: 26 December 2002

Fund Project: We appreciate that this project is supported by the National Natural Science Foundation of China (No. 30070861).

A series of novel 9-fluoro-10-(4-methylpiperazin-1-yl)-3-substituted-8-oxo-8H-[1, 2, 4] triazolo[3, 4-b]thiadiazino[6, 5, 4-ij]quinoline-7-carboxylic acids was prepared by a facile synthetic method and the in vitro antibacterial activity against Gram-postive (G⁺) and Gram negative (G^-) bacteria was primarily evaluated.
- Antibiotics,
- tetracyclicquinolone,
- synthesis,
- antibacterial agents
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