Citation: Hong Gui ZHANG, Xiang Guo SHI, Ying SUN, Ming Yu DUAN, Da Fang ZHONG. New Metabolites of Aconitine in Rabbit Urine[J]. Chinese Chemical Letters, ;2002, 13(8): 758-760. shu

New Metabolites of Aconitine in Rabbit Urine

1.
Department of Natural Pharmaceutical Chemistry, School of Pharmacy, Jilin University, Changchun 130021;
2.
Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Shenyang 110016

Received Date: 28 January 2002

Fund Project: This research project (39870874) was supported by the National Natural Science Foundation of China.

A sensitive analytical method to identify and determine aconitine and its metabolites in rabbit urine was developed by liquid chromatography-electrospray ionization mass spectometry (LC/ESI-MSⁿ).In this method,aconitine and its four metabolites in rabbit urine were isolated and deduced as 16-O-demethylaconine (M1),benzoylaconine(M2),16-O-demethylbenzoylaconine (M3)and aconie(M4).M1 and M3 are new metabolites of aconitine and M2 and M4 are first identified in urine.
- Aconitum,
- metabolites,
- aconitine,
- LC/MS
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