Citation: Cheng He ZHOU, Zhi Chang LIU, Ru Gang XIE, Hua Ming ZHAO. Novel Bis-hydroxymethylation of Imidazole and 2-Methylimidazole[J]. Chinese Chemical Letters, ;1997, 8(1): 21-24. shu

Novel Bis-hydroxymethylation of Imidazole and 2-Methylimidazole

Department of Chemistry, Faculty of Science, Sichuan Union University, Chengdu 610064

Received Date: 16 September 1996

Fund Project: This work is supported by the Special Funds of the State Educational Committee for Doctorate Scientific Research and the National Natural Science Foundation of P. R. China.

A novel one-pot synthesis of 4,5-bis(hydroxymethyl) imidazoles 2a-b,new ethers 3a-b and a new type of imidazolophane 4b by the bis-hydroxymethylation of imidazole or 2-methyl imidazole with formaldehyde and potassium hydroxide is reported.The structures of these compounds have been established by MS,¹HNMR,IR and elemental analyses.
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