Citation: Wen Luxin, Xu Yi, Xiang Songtao, Chen Li. Progress in Endotoxin Detection Based on Biosensor[J]. Chemistry, ;2018, 81(1): 29-36. shu

Progress in Endotoxin Detection Based on Biosensor

Wen Luxin ^1,3,4 ,
Xu Yi ^1,2,3,5,, ,
Xiang Songtao ^1,3,4 ,
Chen Li ^1,2,3,5,,

1.
Key Disciplines Lab of Novel Micro-nano Devices and System Technology, Chongqing University, Chongqing 400030
2.
Key Laboratory for Optoelectronic Technology & System of Ministry of Education, Chongqing University, Chongqing 400044
3.
International R & D Center of Micro-nano Systems and New Materials Technology, Chongqing University, Chongqing 400030
4.
School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030
5.
School of Optoelectronics Engineering, Chongqing University, Chongqing 400044

Corresponding author: Xu Yi, xuyibbd@sina.com Chen Li, cl2009@cqu.edu.cn
Received Date: 13 July 2017
Accepted Date: 12 September 2017

Figures(3)

Endotoxin is well established as a main reason for endoxemia and organs failure, which are severely harmful to human health. So far, much more attention has been paid to develop a efficient and sensitive detection method with high specificity. Because of the superior efficiency and sensitivity, easy to automation and miniaturization, biosensors which is confronted with substantial development space is playing an increasingly important role in the field of endotoxin detection. In this paper, the detection methods of endotoxin in recent years were introduced briefly, and then paid special emphasis on summarizing the optical and electrochemical biosensors applied in endotoxin detection. The challenges and development prospects of endotoxin detection by biosensors are also reviewed.
- Endotoxin,
- LPS,
- Biosensor,
- Ultrasensitive detection
1. [1]
  A H Ding, F Porteu, E Sanchez et al. Science, 1990, 248(4953):370~372.
2. [2]
  APreston, R E Mandrell, B W Gibson et al. Crit. Rev. Microbiol., 1996, 22(3):139~180.
3. [3]
  J Bhattacharyya, S Biswas, A G Datta. Curr. Med. Chem., 2004, 11(3):359~368.
4. [4]
  N Hirata, Y Yanagawa, M Satoh et al. Cell. Immunol., 2010, 261(1):37~41.
5. [5]
  K Lawrence. Crit. Care Nurs. Clin. North Am., 2011, 23(2):323~327.
6. [6]
  K Brandenburg, A B Schromm, T Gutsmann. Curr. Top. Med. Chem., 2004, 4(11):1127~1146.
7. [7]
  C Y Park, S H Jung, J P Bak et al. Biologicals, 2005, 33(3):145~151.
8. [8]
  J F Cooper, J Levin, W H Jr. J. Lab. Clin. Med., 1971, 78(1):138~143.
9. [9]
  J S Bolden, R E Warburton, R Phelan et al. Biologicals, 2016, 44(5):434~440.
10. [10]
  T Liu, W Zhang, L Zhou et al. Anal. Chim. Acta, 2017, 961(1):106~111.
11. [11]
  J F Cooper, M E Weary, F T Jordan. PDA J. Pharm. Sci. Tech., 1997, 51(1):2~6.
12. [12]
  P F Roslansky, T J Novitsky. J. Clin. Microbiol., 1991, 29(11):2477~2483.
13. [13]
  A H Mohammed, D E Mccallus, N L Norcross. Vet. Microbiol., 1988, 18(1):27~39.
14. [14]
  M I Prodromidis. Electrochim. Acta, 2010, 55(14):4227~4233.
15. [15]
  A Turner. Trends Biotechnol., 2013, 31(3):119~120.
16. [16]
  G S Wilson, R Gifford. Biosens. Bioelectron., 2005, 20(12):2388~2403.
17. [17]
  X Fan, I M White, S I Shopova et al. Anal. Chim. Acta, 2008, 620(1/2):8~26.
18. [18]
  A Zuzuarregui, D Souto, E Pérez-Lorenzo et al. Analyst, 2015, 140(2):654~660.
19. [19]
  A Zuzuarregui, M C Morant-Minana, E Perez-Lorenzo et al. IEEE Sens. J., 2013, 14(1):270~277.
20. [20]
  C Luo, Y Yan, T Yu et al. Electroanalysis, 2012, 24(5):1186~1191.
21. [21]
22. [22]
  X L Xiong, S M Wang, Y Zhang et al. Appl. Mech. Mater., 2012, 195~196(1):874~878.
23. [23]
  S M Borisov, O S Wolfbeis. Chem. Rev., 2008, 108(2):423~427.
24. [24]
  E A James, K Schmeltzer, F S Ligler. Appl. Biochem. Biotechnol., 1996, 60(3):189~202.
25. [25]
  S Voss, R Fischer, G Jung et al. J. Am. Chem. Soc., 2012, 129(3):554~561.
26. [26]
  J Wu, A Zawistowski, M Ehrmann et al. J. Am. Chem. Soc., 2011, 133(25):9720~9723.
27. [27]
  M Lan, J Wu, W Liu et al. J. Am. Chem. Soc., 2012, 134(15):6685~6694.
28. [28]
  S Ebrahim, M Reda, A Hussien et al. Spectrochim. Acta A, 2015, 150(1):212~219.
29. [29]
  K L Seng, P Chen, F L Lee et al. Anal. Chem., 2015, 87(18):9408~9412.
30. [30]
  R Chaney, J Rider, D Pamphilon. Transfusion Med., 1999, 9(3):177~188.
31. [31]
  D R Shelton, J S Karns. Appl. Environ. Microbiol., 2001, 67(7):2908~2915.
32. [32]
  S Xie, Y Dong, Y Yuan et al. Anal. Chem., 2016, 88(10):5218~5224.
33. [33]
  B Barlen, S D Mazumdar, O Lezrich et al. Sensors, 2007, 7(8):1427~1446.
34. [34]
  P D Keathley, J T Hastings. Plasmonics, 2012, 7(1):59~69.
35. [35]
  X Dou, B M Phillips, P Y Chung et al. Optics Lett., 2012, 37(17):3681~3683.
36. [36]
  U Yogeswaran, S M Chen. Sensors, 2008, 8(1):290~313.
37. [37]
  X Luo, J J Davis. Chem. Soc. Rev., 2013, 42(13):5944~5947.
38. [38]
  M Mehrvar, M Abdi. Anal. Sci., 2004, 20(8):1113~1126.
39. [39]
  L Lu, G Chee. Biosens. Bioelectron., 2013, 42(1):492~495.
40. [40]
  E Katz, I Willner. Electroanalysis, 2010, 15(11):913~947.
41. [41]
  J T Cao, X Y Hao, Y D Zhu et al. Anal. Chem., 2012, 84(15):6775~6782.
42. [42]
  J A Ho, H C Chang, W T Su. Anal. Chem., 2012, 84(7):3246~3253.
43. [43]
  W Su, M Lin, H Lee et al. Biosens. Bioelectron., 2012, 32(1):32~36.
44. [44]
  M Cho, L Chun, M Lin et al. Sens. Actuat. B, 2012, 174(3):490~494.
45. [45]
  M D Oliveira, C A Andrade, M T Correia et al. J. Colloid Interf. Sci., 2011, 362(1):194~201.
46. [46]
  W Su, S E Kim, M Cho et al. Innate Immun., 2013, 19(4):388~397.
47. [47]
  P Miao. RSC Adv., 2013, 3(25):9606~9617.
48. [48]
  N Y Wu, W Gao, X L He et al. Biosens. Bioelectron., 2013, 39(1):210~214.
49. [49]
  G A Zelada-Guillén, J L Sebastián-Avila, P Blondeau et al. Biosens. Bioelectron., 2012, 31(1):226~232.
50. [50]
  L Bai, Y Chai, X Pu et al. Nanoscale, 2014, 6(5):2902~2908.
51. [51]
  M R Guascito, D Chirizzi, C Malitesta et al. Electrochem. Commun., 2012, 22(8):45~48.
52. [52]
  Z D Gao, Y Qu, T Li et al. Sci. Reports, 2014, 137(4):5113~5122.
53. [53]
  A D Ryabov, R Cerón-Camacho, O Saavedra-Díaz et al. Anal. Chem., 2012, 84(21):9096~9100.
54. [54]
  K Y Inoue, M Matsudaira, R Kubo et al. Lab Chip, 2012, 12(18):3481~3490.
55. [55]
  P Miao, K Han, J Qi et al. Electrochem. Commun., 2013, 26(1):29~32.
56. [56]
  Y H Lin, S H Chen, Y C Chuang et al. Biosens. Bioelectron., 2008, 23(12):1832~1837.
57. [57]
  J Wang. Biosens. Bioelectron., 2006, 21(10):1887~1892.
58. [58]
  R Monošík, M Stred' ansky', E Šturdík. J. Clin. Lab. Anal., 2012, 26(1):22~34.
59. [59]
  G Yang, F Zhao, B Zeng. Biosens. Bioelectron., 2014, 53(9):447~452.
60. [60]
  D S Hélder, J O G Pacheco, M M E Júlia et al. Biosens. Bioelectron., 2014, 52(2):56~61.
61. [61]
  T Gan, J Sun, W Meng et al. Food Chem., 2013, 141(4):3731~3737.
62. [62]
  L Rassaei, F Marken, M Sillanpää et al. Trends Anal. Chem., 2011, 30(11):1704~1715.
63. [63]
  M I Mead, O A M Popoola, G B Stewart et al. Atmos. Environ., 2013, 70(2):186~203.
64. [64]
  R L Bunde, E J Jarvi, J J Rosentreter. Talanta, 1998, 46(6):1223~1236.
65. [65]
  K G Ong, J M Leland, K Zeng et al. Biosens. Bioelectron., 2006, 21(12):2270~2274.
66. [66]
  H Muramatsu, M Suda, T Ataka et al. Sens. Actuat. A, 1990, 21(1):362~368.
67. [67]
  S Sheikh, C Blaszykowski, A Romaschin et al. RSC Adv., 2016, 6(44):38037~38041.
1. [1]
  Yang Meiqing , Lu Wang , Haozi Lu , Yaocheng Yang , Song Liu . Recent Advances of Functional Nanomaterials for Screen-Printed Photoelectrochemical Biosensors. Acta Physico-Chimica Sinica, 2025, 41(2): 100018-0. doi: 10.3866/PKU.WHXB202310046
2. [2]
  Qinqi Zhang , Zhuoran Bi , Yi Zhong , Ziting Xu , Lanlan Chen . 双重信号放大功能核酸荧光探针用于水中抗生素的超灵敏检测. University Chemistry, 2026, 41(5): 448-454. doi: 10.12461/PKU.DXHX202511151
3. [3]
  Ke Zhao , Zhen Liu , Luyao Liu , Changyuan Yu , Jingshun Pan , Xuguang Huang . Functionalized Reflective Structure Fiber-Optic Interferometric Sensor for Trace Detection of Lead Ions. Acta Physico-Chimica Sinica, 2024, 40(4): 2304029-0. doi: 10.3866/PKU.WHXB202304029
4. [4]
  Junlin Ma , Enze Wang , Haixia Wu . 柔性电化学传感器的制备及其在重金属离子现场便携检测中的应用. University Chemistry, 2026, 41(5): 455-468. doi: 10.12461/PKU.DXHX202509102
5. [5]
  Jianfang QIN , Yuying ZHANG , Lijuan JIA , Jiaqi LIANG , Yuxing YANG , Haiying YANG , Xu LIU . Accurate determination of profenofos by Au_25-xAg_x(PET)₁₈ (PET=2-phenylethanethiol) nanocluster-based electrochemical sensors. Chinese Journal of Inorganic Chemistry, 2026, 42(6): 1164-1174. doi: 10.11862/CJIC.20250378
6. [6]
  Qiaoqiao BAI , Anqi ZHOU , Xiaowei LI , Tang LIU , Song LIU . Construction of pressure-temperature dual-functional flexible sensors and applications in biomedicine. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2259-2274. doi: 10.11862/CJIC.20240128
7. [7]
  Lin′an CAO , Dengyue MA , Gang XU . Research advances in electrically conductive metal-organic frameworks-based electrochemical sensors. Chinese Journal of Inorganic Chemistry, 2025, 41(10): 1953-1972. doi: 10.11862/CJIC.20250160
8. [8]
  Wei Zheng , Yanyu Chen , Rizhong Gao , Chao Lu . Development and Application of Primary Battery-based Humidity Sensors: Advancing a New Paradigm for Integrated Experimental Teaching through Science-Education Synergy. University Chemistry, 2026, 41(4): 393-399. doi: 10.12461/PKU.DXHX202503009
9. [9]
  Xingchao Zhao , Xiaoming Li , Ming Liu , Zijin Zhao , Kaixuan Yang , Pengtian Liu , Haolan Zhang , Jintai Li , Xiaoling Ma , Qi Yao , Yanming Sun , Fujun Zhang . Photomultiplication-Type All-Polymer Photodetectors and Their Applications in Photoplethysmography Sensor. Acta Physico-Chimica Sinica, 2025, 41(1): 100007-0. doi: 10.3866/PKU.WHXB202311021
10. [10]
  Jiarong Feng , Yejie Duan , Chu Chu , Dezhen Xie , Qiu'e Cao , Peng Liu . Preparation and Application of a Streptomycin Molecularly Imprinted Electrochemical Sensor: A Suggested Comprehensive Analytical Chemical Experiment. University Chemistry, 2024, 39(8): 295-305. doi: 10.3866/PKU.DXHX202401016
11. [11]
  Tiantian MA , Sumei LI , Chengyu ZHANG , Lu XU , Yiyan BAI , Yunlong FU , Wenjuan JI , Haiying YANG . Methyl-functionalized Cd-based metal-organic framework for highly sensitive electrochemical sensing of dopamine. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 725-735. doi: 10.11862/CJIC.20230351
12. [12]
  Xinrong Wu , Yingying Ren , Jianxue Wang , Lijin Yang , Jia Jia , Nan Li , Na Zhao . 聚光捕胺——高灵敏胺响应型聚集诱导发光探针的合成及传感应用. University Chemistry, 2026, 41(5): 180-189. doi: 10.12461/PKU.DXHX202509129
13. [13]
  Yuyang Xu , Ruying Yang , Yanzhe Zhang , Yandong Liu , Keyi Li , Zehui Wei . Research Progress of Aflatoxins Removal by Modern Optical Methods. University Chemistry, 2024, 39(11): 174-181. doi: 10.12461/PKU.DXHX202402064
14. [14]
  Jing SU , Bingrong LI , Yiyan BAI , Wenjuan JI , Haiying YANG , Zhefeng Fan . Highly sensitive electrochemical dopamine sensor based on a highly stable In-based metal-organic framework with amino-enriched pores. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1337-1346. doi: 10.11862/CJIC.20230414
15. [15]
  Jun LUO , Baoshu LIU , Yunchang ZHANG , Bingkai WANG , Beibei GUO , Lan SHE , Tianheng CHEN . Europium(Ⅲ) metal-organic framework as a fluorescent probe for selectively and sensitively sensing Pb²⁺ in aqueous solution. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2438-2444. doi: 10.11862/CJIC.20240240
16. [16]
  Yun Chen , Daijie Deng , Li Xu , Xingwang Zhu , Henan Li , Chengming Sun . Covalent bond modulation of charge transfer for sensitive heavy metal ion analysis in a self-powered electrochemical sensing platform. Acta Physico-Chimica Sinica, 2026, 42(1): 100144-0. doi: 10.1016/j.actphy.2025.100144
17. [17]
  Shengbiao Zheng , Liang Li , Nini Zhang , Ruimin Bao , Ruizhang Hu , Jing Tang . Metal-Organic Framework-Derived Materials Modified Electrode for Electrochemical Sensing of Tert-Butylhydroquinone: A Recommended Comprehensive Chemistry Experiment for Translating Research Results. University Chemistry, 2024, 39(7): 345-353. doi: 10.3866/PKU.DXHX202310096
18. [18]
  Chenfei Li , Xu Han , Qimeng Zhang , Ben Zhang , Xinyao Huang , Mingxiao Deng , Caixia Zheng , Haizhu Sun . Measurement of Stress-Strain Curves of Polymeric Materials Using a Non-Contact Displacement Detector. University Chemistry, 2026, 41(1): 179-187. doi: 10.12461/PKU.DXHX202505101
19. [19]
  Xiaowei TANG , Shiquan XIAO , Jingwen SUN , Yu ZHU , Xiaoting CHEN , Haiyan ZHANG . A zinc complex for the detection of anthrax biomarker. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1850-1860. doi: 10.11862/CJIC.20240173
20. [20]
  Jinghan ZHANG , Guanying CHEN . Progress in the application of rare-earth-doped upconversion nanoprobes in biological detection. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2335-2355. doi: 10.11862/CJIC.20240249

Get Citation

PDF

XML

Metrics

PDF Downloads(33)
Abstract views(7499)
HTML views(2151)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142