Citation: Ai Ye LIANG, Yu Guang DU, Ke Yi WANG, Bing Cheng LIN. Capillary Zone Electrophoresis Investigation of Interactions between Granulocyte-colony Stimulating Factor and Dextran Sulfate/Carrageenan Oligosaccharide[J]. Chinese Chemical Letters, ;2005, 16(5): 647-650. shu

Capillary Zone Electrophoresis Investigation of Interactions between Granulocyte-colony Stimulating Factor and Dextran Sulfate/Carrageenan Oligosaccharide

1.
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023;
2.
Institute of Biochemistry and Cell Biology, Shanghai Academy of Life Science, Chinese Academy of Sciences, Shanghai 200031

Received Date: 9 May 2004

Fund Project: The authors would like to acknowledge the support from the National Natural Science Foundation of China (Project number 20299035, 20035010, 20275039) and Pilot of Knowledge Innovation Program of the Chinese Academy of Science (KSCX 2-3-02-02) on the above work. We would also like to thank Qilu Pharmaceutical Factory for providing chemicals essential to the project.

The interactions between granulocyte-colony stimulating factor (G-CSF) and dextran sulfate/κ-carrageenan oligosa1ccharide were studied by capillary zone electrophoresis. Dextran sulfate could strongly interact with G-CSF and the complex was detected. The binding constant and stoichiometry were determined to be 1.2×10⁶ (mol/L)^-1 and 3:1, respectively. However, the interaction between κ-carrageenan oligosaccharide and G-CSF was not found.
- Capillary zone electrophoresis,
- granulocyte-colony stimulating factor,
- dextran sulfate,
- κ-carrageenan oligosaccharide,
- interaction
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