Citation: Raphael M.Ottenbrite, Sam Milstein. UNIQUE ORAL DRUG DELIVERY SYSTEM[J]. Chinese Journal of Polymer Science, ;1995, 13(4): 315-321. shu

UNIQUE ORAL DRUG DELIVERY SYSTEM

Received Date: 30 December 1994

An oral drug delivery system using proteinoid microspheres is discussed with respect to itsunique dependence on pH. It has been found that certain drugs such as insulin and heparin canbe encapsulated in proteinoid spheres at stomach pH's (1--3). These spheres also dissemble atintestinal pH's (6--7) releasing the drug for absorption. Using this technique low molecularweight heparin and human growth hormone have been orally delivered successfully to severalanimal species. Future work has been proposed to study the interaction and binding of the specific drugs with synthesized oligopeptides.
1. [1]
  Peishuang Yu , Bohan Chen , Bingyu Xie , Mengjiao Zhou , Chengying Wang , Shenshen Yang , Wei Huang , Yubo Li . Recent advances in oral hydrogel drug delivery system for disease treatment. Chinese Chemical Letters, 2026, 37(7): 111695-. doi: 10.1016/j.cclet.2025.111695
2. [2]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
3. [3]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
4. [4]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
5. [5]
  Baoqing Liu , Zimeng Li , Xiandong Shi , Jingyi Zhang , Heming Wu , Hailong Liu , Jiahong Zhou . An SCC-9 cell uptake-specific extracellular vesicle drug delivery system for tongue cancer therapy. Chinese Chemical Letters, 2026, 37(7): 111748-. doi: 10.1016/j.cclet.2025.111748
6. [6]
  Jiechen Liu , Xiaoguang Li , Ruiyang Xia , Yuqi Wang , Fenghe Zhang , Yongzhi Pang , Qing Li . Efficient suppression of oral squamous cell carcinoma through spatial dimension conversion drug delivery systems-enabled immunomodulatory-photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109619-. doi: 10.1016/j.cclet.2024.109619
7. [7]
  Qin Yu , Haisheng He , Jianping Qi , Yi Lu , Wei Wu . Oral delivery of insulin by barbed microneedles actuated by intestinal peristalsis. Chinese Chemical Letters, 2024, 35(9): 109888-. doi: 10.1016/j.cclet.2024.109888
8. [8]
  Juan Tao , Jinlong Yang , Mengyu Zhao , Quangang Zhu , Zhongjian Chen , Jianping Qi . Emerging trends in permeation-enhancing technologies for oral peptide delivery. Chinese Chemical Letters, 2026, 37(3): 111170-. doi: 10.1016/j.cclet.2025.111170
9. [9]
  Li Yang , Yuhong Gong , Liqing Mo , Ting Zhu , Yingxuan Dai , Xinrui Hu , Yuxi Zhu , Yi Zhao , Jianhua He . Drug delivery systems for the treatment of venous thrombosis. Chinese Chemical Letters, 2026, 37(9): 111983-. doi: 10.1016/j.cclet.2025.111983
10. [10]
  Taozhen Li , Zhuohang Wu , Shu Yang , Bin Li , Semencha Alexander Vyacheslavovich , Donaev Sardor Burkhanovich , Ergashev Yorqinjon Tolqinogli , Rashidov Shokhzodbek Abduvakhobovich , Lei Wang , Jingwen Pan . Revealing the unique generation pathway of singlet oxygen from sulfate radical in Fe-based Fenton-like system. Chinese Chemical Letters, 2026, 37(9): 112443-. doi: 10.1016/j.cclet.2026.112443
11. [11]
  Zhengzheng Lv , Xin Xia , Peisheng Cao , Qi Han , Hang Zhao , Ronghui Zhou , Peng Wu . Overcoming the drug retention barrier with photosensitive hydrogel for sustained photodynamic therapy of oral leukoplakia. Chinese Chemical Letters, 2026, 37(5): 111282-. doi: 10.1016/j.cclet.2025.111282
12. [12]
  Qiannan Cao , Yu Liang , Weiyi Xia , Anna Guo , Mingxia Jiang , Lai Yang , Qiaoyan Dong , Wenming Zheng , Yingli Yao , Siting Zhang , Huilin Yuan , Pijun Su , Rongmei Zhou , Songyu Xu , Bo Chen , Jing Yao , Huapan Fang , Huayu Tian . Polycation-based miRNA delivery system for choroidal neovascularization treatment. Chinese Chemical Letters, 2026, 37(9): 112031-. doi: 10.1016/j.cclet.2025.112031
13. [13]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
14. [14]
  Jing Feng , Yanhong Liu , Liming Gong , Chenfei Liu , Congcong Xiao , Liqing Chen , Mingji Jin , Zhonggao Gao , Wei Huang , Yubo Li . Recent progress on drug delivery systems of regulating intratumoral bacteria for tumor therapy. Chinese Chemical Letters, 2025, 36(11): 110907-. doi: 10.1016/j.cclet.2025.110907
15. [15]
  Yan Yu , Cailing Gan , Kun Shi , Zhongwu Bei , Yang Yu , Meng Pan , Hanzhi Deng , Zhiyong Qian . Recent advances in drug delivery systems for pulmonary fibrosis therapy. Chinese Chemical Letters, 2026, 37(1): 111596-. doi: 10.1016/j.cclet.2025.111596
16. [16]
  Yiyao Wan , Wen Chen , Yan Yu , Meng Pan , Kun Shi , Zhiyong Qian . Biomaterial-based drug delivery systems for the therapy of malignant pleural effusion. Chinese Chemical Letters, 2026, 37(1): 111513-. doi: 10.1016/j.cclet.2025.111513
17. [17]
  Guanlong Li , Zhuoyan Li , Yan Sun , Tiange Bu , Shaochuan Chen , Leixin Yang , Zhi Li , Wenyue Mao , Yanpeng Jia . Advances in CNS drug delivery strategies to cross the blood-brain barrier. Chinese Chemical Letters, 2026, 37(1): 111524-. doi: 10.1016/j.cclet.2025.111524
18. [18]
  Jia-Lun Duan , Xin-Lan Zhang , Li-Qiang Zhao , Ya-Nan Liu , An-Ni Yao , Nian-Guang Li , Jin-Ao Duan , Chun-Jie Bao . Macrophage membrane-camouflaged nanoparticles for targeted drug delivery. Chinese Chemical Letters, 2026, 37(7): 111610-. doi: 10.1016/j.cclet.2025.111610
19. [19]
  Yuke Ji , Jia Liang , Xiangqing Hei , Lu Chen , Shudong Yu , Dong Fang , Hui Tan , Shaochong Zhang . Nanomaterial-based drug delivery systems for ocular diseases: A review. Chinese Chemical Letters, 2026, 37(9): 112062-. doi: 10.1016/j.cclet.2025.112062
20. [20]
  Junfei Yang , Ke Wang , Shuxin Sun , Tianqi Pei , Junxiu Li , Xunwei Gong , Cuixia Zheng , Yun Zhang , Qingling Song , Lei Wang . A "spore-like" oral nanodrug delivery platform for precision targeted therapy of inflammatory bowel disease. Chinese Chemical Letters, 2025, 36(3): 110180-. doi: 10.1016/j.cclet.2024.110180

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(1742)
HTML views(67)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return