Citation: Raphael M.Ottenbrite, Sam Milstein. UNIQUE ORAL DRUG DELIVERY SYSTEM[J]. Chinese Journal of Polymer Science, ;1995, 13(4): 315-321. shu

UNIQUE ORAL DRUG DELIVERY SYSTEM

Received Date: 30 December 1994

An oral drug delivery system using proteinoid microspheres is discussed with respect to itsunique dependence on pH. It has been found that certain drugs such as insulin and heparin canbe encapsulated in proteinoid spheres at stomach pH's (1--3). These spheres also dissemble atintestinal pH's (6--7) releasing the drug for absorption. Using this technique low molecularweight heparin and human growth hormone have been orally delivered successfully to severalanimal species. Future work has been proposed to study the interaction and binding of the specific drugs with synthesized oligopeptides.
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