Citation: Jun Biao CHANG, Rui Yun GUO, Juan HE, Rong Feng CHEN. Synthesis of N⁶-Cyclopropy1-2,6-diamino-9 β-D-arabinofuranosylpurine[J]. Chinese Chemical Letters, ;1999, 10(5): 357-360. shu

Synthesis of N⁶-Cyclopropy1-2,6-diamino-9 β-D-arabinofuranosylpurine

Henan Institute of Chemistry, Zhengzhou 450003

Received Date: 11 September 1998

Synthesis of N⁶-cvclopropyl-2,6-diamino-9 β-D-arabinofuranosyl-purine has been accomplished by treatment ailylated 2-amino-6-chloro-purine 4 with 2.3.5-tri-O-benzyl-β-D-arabinofuranosyl chloride 3 in the presence of molecular sieves follwed by reaction with cyclopropylamine and debenzyl reaction to give the β-anomeric nucleoside. The structures of all products were confirmed by UV. ¹H-NMR and elemental analysis.
- Cyclopropylamine,
- arabinofuranose,
- purnie