Citation: De Xin Wang, Gui Shen Lu. TRIFLUOROMETHANESULFONIC ACID AS A USEFUL REAGENT FOR CLEAVAGEOF PEPTIDYL RESIN[J]. Chinese Chemical Letters, ;1990, 1(2): 155-156. shu

TRIFLUOROMETHANESULFONIC ACID AS A USEFUL REAGENT FOR CLEAVAGEOF PEPTIDYL RESIN

De Xin Wang ,
Gui Shen Lu

Institute of Materia Mediea, Chinese Academy of Medical Sciences, 1 Xian Nong Tan St., Beijing 100050, China

Received Date: 23 October 1989

The efficiency of TFMSA as a cleaving reagent for peptidyl resin(I-VⅢ) was evaluated by quantitative ninhydrin test of peptide substitution degree (SD) on resin.Under different conditions,such as variation of C-terminal residue,resin linkage,the temperature and reaction time etc.,TFMSA can be used very conveniently instead of HF in many cases.
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