Citation: Ling Tian TANG, Yi WANG, Xin Qi LIU, Shao Wen HU, Tai Wei CHU, Xiang Yun WANG. Synthesis, Characterization, Spectroscopic Properties of 2-(4-Dimethylaminophenyl)-5-fluoro-6-(morpholin-4-yl)-1H-benzimidazole and its Interaction with Calf Thymus DNA[J]. Chinese Chemical Letters, ;2005, 16(3): 345-348. shu

Synthesis, Characterization, Spectroscopic Properties of 2-(4-Dimethylaminophenyl)-5-fluoro-6-(morpholin-4-yl)-1H-benzimidazole and its Interaction with Calf Thymus DNA

College of Chemistry and Molecular Engineering, Peking University, Beijing 100871

Received Date: 8 March 2004

Fund Project: This work was financially supported by the National Natural Science Foundation of China (20171005). The authors thank professor Hong Cheng GAO and Na LI of Peking University for their meaningful suggestions and discussions.

2-(4-Dimethylaminophenyl)-5-fluoro-6-(morpholin-4-yl)- 1H-benzimidazole(1) has been synthesized and characterized by ¹H-NMR, MS and elemental analysis. UV-Vis spectra of the aqueous solutions at different pH values reveal that compound 1 can combine three protons. Its three protonation constants are determined by spectrophotometry and calculated by non-linear least squares. The results of steady-state fluorescence measurements indicate that a special interaction occurs between compound 1 and calf thymus DNA, of which the binding constant, K_b, is (2.30 ±0.10)×l0⁴ L/mol. Compound 1 in the concentration range of 10^-8 to 1.2×l0^-6 mol/L could be used for quantitative determination of DNA.
- 2-(4-Dimethylaminophenyl)-5-fluoro-6-(morpholin-4-yl)-lH-benzimidazole,
- calf thymus DNA.
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