Two Novel Antifungal Saponins from Tibetan Herbal Medicine Clematis tangutica

Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204

Received Date: 27 August 2002

Fund Project: This work was supported by the Ministry of Science and Technology grant 2001-51, the National Natural Science Foundation of China (30070007), Natural Science Foundation of Yunnan Province (99B0017G). The authors are grateful to Ms. ZheRenWangMu in Tibetan Institute of Plateau Biology for providing plant materials, and to Prof. D. Z. Wang, Mr. Y. N. He, Ms. H. L. Liang and Ms. Y. Wu in the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, for measuring 2D NMR, 1D NMR and MS data, respectively. Mr. J. X. Zhang in the Key Laboratory of Natural Products Chemistry of Guizhou Province and the Chinese Academy of Sciences, Guiyang 650204 obtained the ID and 2D NMR spectra on INOVA-400.

Antifungal assay-guided isolation of the ethanol extract of the aerial parts of Clematis tangutica yielded two novel triterpene saponins. Their structures were determined to be 3-O-α-L-arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester (1) and 3-O-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester (2) on the basis of spectral data and chemical reactions.

Two Novel Antifungal Saponins from Tibetan Herbal Medicine Clematis tangutica

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