Citation: Jun Bo WANG, Chun Hao YANG, Xue Ming YAN, Xi Han WU, Yu Yuan XIE. Novel Bone-targeted Agents for Treatment of Osteoporosis[J]. Chinese Chemical Letters, ;2005, 16(7): 859-862. shu

Novel Bone-targeted Agents for Treatment of Osteoporosis

State Key Lab of Drug Discovery, Shanghai Institute of Materia Medica, SIBS, CAS, Shanghai 201203

Received Date: 12 July 2004

The novel bone-targeted agents were designed and synthesized by the combination of raloxifene and bisphosphonates. The anti-osteoporosis effect was evaluated by bone mineral density (BMD) obtained from OVX mice in vivo. The results indicated that the compound 8, 9 not only prevented ovariectomy induced loss of bone but also enhanced BMD to 0.87% and 19.67% compared to Sham, respectively.
- Osteoporosis,
- bone-targeted,
- raloxifene,
- bisphosphonate
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