Citation: Song Qing WANG, Lin FANG, Xiu Jie LIU, Kang ZHAO. Design,Synthesis,and Hypnotic Activity of Pyrazolo[1,5-a]pyrimidine Derivatives[J]. Chinese Chemical Letters, ;2004, 15(8): 885-888. shu

Design,Synthesis,and Hypnotic Activity of Pyrazolo[1,5-a]pyrimidine Derivatives

1.
College of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016;
2.
College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072

Received Date: 9 July 2003

On the basis of the Zaleplon structure, novel pyrazolo[1,5-a]pyrimidines were designed and prepared for studies on their hypnotic activity.This paper reported the synthesis of twelve new 5-methyl-7-substituted-pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives by using simple starting materials such as propane dinitrile and triethyl orthoformate.The structures of the derived target compounds were confirmed by their IR and ¹H-NMR spectroscopic data.The preliminary pharmacological evaluations indicated that some compounds showed hypnotic activity, while derivative 1c was the most potent one.
- GABA,
- hypnotic drug,
- synthesis,
- pyrazolo[1,5-a]pyrimidines
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