Citation: Min ZHU, Xue Mei HUANG, Han Xi SHEN. Activation of Carcinogenic Non-aminoazo Compounds in Horseradish Peroxidase/H₂O₂ System[J]. Chinese Chemical Letters, ;1997, 8(11): 979-982. shu

Activation of Carcinogenic Non-aminoazo Compounds in Horseradish Peroxidase/H₂O₂ System

Department of Chemistry, Nankai University, Tianjin, 300071

Received Date: 23 June 1997

Fund Project: Authors would be grateful to the National Natural Science Foundation of China for the financial support.

Eriochrome black T and Nitrosulfophenol S were advocated as the chemical models of carcinogenic non-aminoazo compounds.The main products of their oxidative cleavage in horseradish peroxidase/H₂O₂ system was identified as the benezenediazonium ion,the ultimate carcinogens,which could bind to DNA.The reaction conditions were investigated preliminarily.Some inhibitors and inducers of the reaction were discovered.
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