Citation: He Gui GONG, Hua FU, Zhao Long LI, Yu Fen ZHAO. ³¹P NMR Spectral Evidence for the Formation of Amino Acid Highcoordinated Phosphorus Intermediates[J]. Chinese Chemical Letters, ;1998, 9(10): 953-955. shu

³¹P NMR Spectral Evidence for the Formation of Amino Acid Highcoordinated Phosphorus Intermediates

Bioorganic phosphorus chemistry Lab., Department of Chemistry, Tsinghua Univ., Beijing 100084

Received Date: 27 April 1998

Fund Project: We thank the National Natural Science Foundation and the Science Foundation of Tsinghua University.

The active intermediates of hexacoordinated 4-nitrotrispirophosphoric amino acid (P(6)-AA), which were formed by the reaction of 4-nitro-0,0-phenylene phosphochloridate (NO-PPC) with silanizing serine, threonine and cysteine, were observed by ³¹P NMR spectra. The reaction mechanism of these processes was discussed. In addition, some interesting results were observed by mixing 4-nitro-2,2,2-tricloro-l,3, 2-benzodioxaphosph(v)ole (NTB) with silanizing serine and histidine.
- highcoordinated phosphorus,
- amino acids
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