Citation: Lang Tao SHEN, Ting YANG, Hong Yu LI, Ji HU, Zhi Fu LUO. Synthesis of a Novel Chiral Trihydroxamic Acid Containing L-Pro-L-Ala-L-Ala-β-(HO)Ala-OMe Unit[J]. Chinese Chemical Letters, ;2006, 17(6): 751-754. shu

Synthesis of a Novel Chiral Trihydroxamic Acid Containing L-Pro-L-Ala-L-Ala-β-(HO)Ala-OMe Unit

Lang Tao SHEN ^1,2, ,
Ting YANG ¹ ,
Hong Yu LI ¹ ,
Ji HU ¹ ,
Zhi Fu LUO ¹

1.
National Isotope Center of Engineering and Technology, China Institute of Atomic Energy, Beijing P. O. Box 275(58), Beijing 102413;
2.
Medical Isotope Research Center, Peking University, Beijing 100083

Received Date: 7 December 2005

Fund Project: This work was supported in part by President Foundation of China Institute of Atomic Energy, Basic Research Foundation of Commission of Science Technology and Industry for National Defense of China and 211 Project of Peking University.

An N-hydroxyl peptide unit of H-L-Pro-L-Ala-L-Ala-β-(BnO)Ala-OMe was synthesized by stepwise chain building method in solution. Then, based on nitrilotriacetic acid backbone and this N-hydroxyl peptide unit, a novel chiral tripodal ligand P as an analogue of desferrichrome, has been synthesized. In neutral pH, ligand P formed stable tri(hydroxamato)-iron(Ⅲ) complexes which showed a maximum absorption (ε_max=2750 M^-1 cm^-1) at 422 nm in UV-Vis spectra. The characteristic absorption spectra are similar to those of natural trihydroxamate-type siderophores.
- Hydroxamic acid,
- siderophores,
- tripodal ligand,
- chelators,
- iron
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