Citation: Yi Chun ZHANG, Ying Xia LI, Hua Shi GUAN. Synthesis of Indomethacin Conjugates with D-Glucosamine[J]. Chinese Chemical Letters, ;2005, 16(2): 179-182. shu

Synthesis of Indomethacin Conjugates with D-Glucosamine

Key Laboratory of Marine Drugs, Ministry of Education, Marine Drug and Food Institute, Ocean University of China, Qingdao 266003

Received Date: 29 December 2003

Two series of indomethacin conjugates with D-glucosamine were prepared with the objectives of reducing ulcerogenic potency, increasing the bioavailability of indomethacin and exerting the coordinative effects on osteoarthritis. The structures of the conjugates were identified by ¹H NMR and ¹³C NMR. The ester conjugates inhibited edema as potent as indomethacin.
- Indomethacin,
- D-glucosamine,
- NSAIDs,
- glycoconjugates.
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